Wyniki wyszukiwania dla: Ye Li

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First East Asian case of uncombable hair syndrome

Ye Li, Xing Xiong, Nicole Cesarato, Maria Wehner, więcej

JDDG: Journal der Deutschen Dermatologischen Gesellschaft > 22 > 10 > 1433 - 1435

artykuł

Erster ostasiatischer Fall des Syndroms der unkämmbaren Haare

Ye Li, Xing Xiong, Nicole Cesarato, Maria Wehner, więcej

JDDG: Journal der Deutschen Dermatologischen Gesellschaft > 22 > 10 > 1433 - 1435

artykuł

Does Screw Number of Zero‐profile Implants in Fusion Segment Influence Intervertebral Stability?

Zihan Peng, Yuxiao Deng, Xiaqing Sheng, Hao Liu, więcej

Orthopaedic Surgery > 16 > 10 > 2355 - 2363

Objective The unclear clinical outcomes of two different zero‐profile implants with different number of screws in hybrid surgery restricts the choice of patient‐specific implants. This study aims to compare two different implants on its postoperative subsidence, motion stabilization and clinical outcomes. It also provides references to the most reasonable implant choice in fusion surgery. Methods...

artykuł

Discovery of 4‐(isopentyloxy)‐3‐nitrobenzamide derivatives as xanthine oxidase inhibitors through a non‐anthraquinone exploration

Shuai Guo, Qi Sun, Xu Zhang, Song‐ye Li, więcej

Archiv der Pharmazie > 357 > 10 > n/a - n/a

In our previous study, we reported a series of N‐(9,10‐anthraquinone‐2‐carbonyl) amino acid derivatives as novel inhibitors of xanthine oxidase (XO). Recognizing the suboptimal drug‐like properties associated with the anthraquinone moiety, we embarked on a nonanthraquinone medicinal chemistry exploration in the current investigation. Through systematic structure–activity relationship (SAR) studies,...

artykuł

Development of sinomenine hydrochloride loaded shell/core nanofibrous with pH‐responsive for colon‐targeted drug delivery

Yanzhi Zhao, Xueqian Ma, Xiufang Zhu, Mingdi Liu, więcej

Journal of Applied Polymer Science > 141 > 40 > n/a - n/a

A series of colon‐targeted, sustained‐release, sinomenine hydrochloride (SH) loaded shell/core electrospun nanofibers are reported. The fibers have shells made of Eudragit S100 (ES‐100), and drug‐loaded cores comprising of Eudragit RS100 (ERS‐100) and SH. The essential characteristics of membranes are evaluated by scanning electron microscopy, transmission electron microscope, Fourier transformed...

artykuł

Progress on the Design of Electrocatalysts for Large‐Current Hydrogen Production by Tuning Thermodynamic and Kinetic Factors

Ye Li, Ao Feng, Linxiu Dai, Baojuan Xi, więcej

Advanced Functional Materials > 34 > 28 > n/a - n/a

Electrochemical water splitting to produce green hydrogen offers a promising technology for renewable energy conversion and storage, as well as realizing carbon neutrality. The efficiency, stability, and cost of electrocatalysts toward hydrogen evolution reaction (HER) and electrocatalytic overall water splitting (EOWS) at large current densities are essential for practical application. In this review,...

artykuł

Using a deep learning prior for accelerating hyperpolarized ¹³C MRSI on synthetic cancer datasets

Zuojun Wang, Guanxiong Luo, Ye Li, Peng Cao

Magnetic Resonance in Medicine > 92 > 3 > 945 - 955

Purpose We aimed to incorporate a deep learning prior with k‐space data fidelity for accelerating hyperpolarized carbon‐13 MRSI, demonstrated on synthetic cancer datasets. Methods A two‐site exchange model, derived from the Bloch equation of MR signal evolution, was firstly used in simulating training and testing data, that is, synthetic phantom datasets. Five singular maps generated from each simulated...

artykuł

B₁ inhomogeneity corrected CEST MRI based on direct saturation removed omega plot model at 5T

Qiting Wu, Pengcheng Gong, Shengping Liu, Ye Li, więcej

Magnetic Resonance in Medicine > 92 > 2 > 532 - 542

Purpose CEST can image macromolecules/compounds via detecting chemical exchange between labile protons and bulk water. B₁ field inhomogeneity impairs CEST quantification. Conventional B₁ inhomogeneity correction methods depend on interpolation algorithms, B₁ choices, acquisition number or calibration curves, making reliable correction challenging. This study proposed a novel B₁ inhomogeneity correction...

artykuł

WRKY6 transcription factor modulates root potassium acquisition through promoting expression of AKT1 in Arabidopsis

Fangfang Niu, Xing Cui, Bo Yang, Rui Wang, więcej

The Plant Journal > 118 > 5 > 1652 - 1667

Potassium (K⁺), being an essential macronutrient in plants, plays a central role in many aspects. Root growth is highly plastic and is affected by many different abiotic stresses including nutrient deficiency. The Shaker‐type K⁺ channel Arabidopsis (Arabidopsis thaliana) K⁺ Transporter 1 (AKT1) is responsible for K⁺ uptake under both low and high external K⁺ conditions. However, the upstream transcription...

artykuł

Diabetes mellitus and Alzheimer's disease: Vacuolar adenosine triphosphatase as a potential link

Bin Guo, Qi‐ye Li, Xue‐jia Liu, Guo‐hui Luo, więcej

European Journal of Neuroscience > 59 > 10 > 2577 - 2595

Globally, the incidence of diabetes mellitus (DM) and Alzheimer's disease (AD) is increasing year by year, causing a huge economic and social burden, and their pathogenesis and aetiology have been proven to have a certain correlation. In recent years, more and more studies have shown that vacuolar adenosine triphosphatases (v‐ATPases) in eukaryotes, which are biomolecules regulating lysosomal acidification...

artykuł

Synthesis of Cu_2‐xSe‐MoSe₂ Edge‐Epitaxial Heterostructure for Efficient Electrocatalytic Hydrogen Evolution

Yanbo Ma, Lei Yang, Ye Li, Hai Li, więcej

Small > 20 > 20 > n/a - n/a

The exposure of active edge sites of transition metal dichalcogenide (TMD) in TMD‐based heterostructures is essential to enhance the catalytic activity toward electrochemical catalytic hydrogen evolution (HER). The construction of TMD‐based edge‐epitaxial heterostructures can maximally expose the active edge sites. However, owing to the 2D crystal structures, it remains a great challenge to vertically...

artykuł

Sevoflurane blocks KLF5‐mediated transcriptional activation of ITGB2 to inhibit macrophage infiltration in hepatic ischemia/reperfusion injury

Ye Li, Weinian Gao, Shuyan Lei, Xiaoning Wu, więcej

The Journal of Gene Medicine > 26 > 5 > n/a - n/a

Background Sevoflurane (Sevo) preconditioning and postconditioning play a protective role against injury induced by hepatic ischemia/reperfusion (I/R). At the same time, the involvement of macrophage infiltration in this process and the precise mechanisms are unclear. Here, we designed this research to elucidate the protective effects of Sevo against hepatic I/R injury and the molecules involved...

artykuł

STAMENLESS1 activates SUPERWOMAN 1 and FLORAL ORGAN NUMBER 1 to control floral organ identities and meristem fate in rice

Hui Zhuang, Yu‐Huan Li, Xiao‐Yu Zhao, Jing‐Ya Zhi, więcej

The Plant Journal > 118 > 3 > 802 - 822

Floral patterns are unique to rice and contribute significantly to its reproductive success. SL1 encodes a C2H2 transcription factor that plays a critical role in flower development in rice, but the molecular mechanism regulated by it remains poorly understood. Here, we describe interactions of the SL1 with floral homeotic genes, SPW1, and DL in specifying floral organ identities and floral meristem...

artykuł

Modeling analysis and experiment for energy system of ocean energy driven unmanned marine vehicle: The Yulang II case study

Qi Jia, Yulei Liao, Peihong Xu, Shuo Pang, więcej

Journal of Field Robotics > 41 > 3 > 735 - 765

It is critical to master a marine robot's energy system characteristics adequately to ensure that the robot can perform long‐endurance tasks in complex and ever‐changing marine environments. This paper presents, for the first time, an energy system modeling and analysis method for a marine robot driven by wind, solar, and wave composite energy, using Yulang II as an example. First, an onshore experiment...

artykuł

CD74–ROS1 L2026M mutant enhances autophagy through the MEK/ERK pathway to promote invasion, metastasis and crizotinib resistance in non‐small cell lung cancer cells

Xiaobo Xu, Ye Li, Rui Xu, Yuting Meng, więcej

The FEBS Journal > 291 > 6 > 1199 - 1219

The treatment of non‐small cell lung cancer (NSCLC) patients harboring a proto‐oncogene tyrosine‐protein kinase c‐ros oncogene 1 (ROS1) fusion gene has greatly benefited from the use of crizotinib. However, drug resistance inevitably occurs after 1 year of treatment. Clinical studies have shown that patients with an L2026M mutation in the ROS1 kinase domain account for about 6% of the total number...

artykuł

Structure‐based design of diarylpyrimidines and triarylpyrimidines as potent HIV‐1 NNRTIs with improved metabolic stability and drug resistance profiles

Minghui Xie, Zhao Wang, Fabao Zhao, Ye Li, więcej

Journal of Medical Virology > 96 > 3 > n/a - n/a

Non‐nucleoside reverse transcriptase inhibitors (NNRTIs) are an important component of anti‐acquired immunodeficiency syndrome treatment regimen. In the present work, with the previously reported compound K‐16c as lead, a series of novel 2,4,5‐trisubstituted pyrimidine derivatives were designed based on the cocrystal structure of K‐16c/RT, with the aim to improve the anti‐human immunodeficiency virus...

artykuł

Uptake of paediatric vision screening in Queensland, Australia: An analysis of socioeconomic factors

Ye Li, Shelley Duffy, Sagen Wilks, Rachel Keel, więcej

Clinical & Experimental Ophthalmology > 52 > 1 > 118 - 121

artykuł

Design and field test of a foldable wing unmanned aerial–underwater vehicle

Xiangren Sun, Jian Cao, Ye Li, Baoxu Wang

Journal of Field Robotics > 41 > 2 > 347 - 373

This paper presents the design and field test of a foldable wing unmanned aerial–underwater vehicle (UAUV). The vehicle can complete diving and air operations, and still have the ability of multiple trans‐medium water egress and ingress under the condition of carrying mission load during a single flight. The wings can be folded back for drag reduction in underwater sailing and water egress, and unfolded...

artykuł

A stereo visual navigation method for docking autonomous underwater vehicles

Shuo Xu, Yanqing Jiang, Ye Li, Bo Wang, więcej

Journal of Field Robotics > 41 > 2 > 374 - 395

Recovering and recharging autonomous underwater vehicles (AUVs) on a regular basis allows for long‐term underwater activities. This research provides a vision‐based navigation strategy for AUVs to independently identify and reconstruct the docking station (DS). The proposed framework includes a light beacon detection approach, a filter‐based light beacon matching method, and a fusion pose estimation...

artykuł

Model‐based dosing optimization and therapeutic drug monitoring practices of teicoplanin in patients with complicated or non‐complicated methicillin‐resistant staphylococcus aureus infection

Xiao‐Shan Zhang, Ye‐Li Chen, Yu‐Zhen Wang, Chuang Chen, więcej

British Journal of Clinical Pharmacology > 90 > 2 > 452 - 462

Aims This study aims to establish a population pharmacokinetic (PK) model of teicoplanin in Chinese adult patients to evaluate the dosing regimen in the label sheet and optimize it. Methods Nonlinear mixed‐effects modelling was used to estimate PK parameters. Monte Carlo simulations were used to evaluate the attainment of various dosing regimens in achieving the target trough concentrations in...

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