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Breast cancer is the most common malignancy in American women aside from skin cancer, and the second leading cause of cancer death, exceeded only by lung cancer. It is estimated that there were 182,460 new breast cancer cases diagnosed in the United States in 2008, and 40,480 deaths. In addition to invasive breast cancer, carcinoma in situ (CIS), the earliest form of breast cancer, accounted for about...
Histone deacetylases (HDACs) are a family of enzymes that regulate chromatin remodeling and gene transcription. Vorinostat is a panHDAC inhibitor that sensitizes breast cancer cells to taxanes and trastuzumab by suppressing HDAC6 and Hsp90 client proteins. Fifty-five patients with clinical stage IIA-IIIC breast cancer received 12 weekly doses of paclitaxel (80 mg/m2) plus vorinostat (200–300 mg PO...
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