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Signaling through cGMP has therapeutic potential in the colon, where it has been implicated in the suppression of colitis and colon cancer. In this study, we tested the ability of cGMP and type 2 cGMP-dependent protein kinase (PKG2) to activate forkhead box O (FoxO) in colon cancer cells and in the colon epithelium of mice. We show that activation of PKG2 in colon cancer cells inhibited cell proliferation,...
Acute upper GI bleeding (UGIB) is a common medical emergency with an annual rate of 150–200 hospitalizations per 100,000 population and a 5–10% mortality rate. It is the result of bleeding from any part of the GI tract proximal to the ligament of Treitz (Lewis et al. 2002).
Wireless video capsule endoscopy (VCE) is a significant advancement in gastrointestinal (GI) imaging for the evaluation of small bowel mucosa. VCE is a noninvasive endoscopic tool comprised of an ingestible 11 × 26 mm capsule. It is a self-contained camera and antenna that transmits images to a sensor array/data recorder worn by a patient. The recorded images captured by the data recorder are downloaded...
The advent of endoscopic ultrasound (EUS) and guided fine needle aspiration (FNA) has significantly altered the management of benign and malignant gastrointestinal, biliary-pancreatic and mediastinal disorders. Over the past two decades, EUS has evolved from being a diagnostic imaging modality to an interventional modality. Several evolving therapeutic applications are paving the way to previously...
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