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A novel biochip, which was made from Polydimethylsiloxane (PDMS) and integrated separation and enrichment structures, has been presented. The biochip mainly composes of the spiral microchannel with pillared filtration structures being used to simultaneously and continuously separate cells, and the U-shaped filter being applied to enrich the cells. The protocol of the soft lithographic methods for...
A miniaturized surface plasmon resonance (SPR) chip has been developed for biomedical and chemical analysis with low cost and high performance. The techniques of bulk silicon micromachining and polymer replication were used to fabricate the Kretschmann SPR sensor composed of a Polydimethylsiloxane (PDMS) prism, a coupling glass and microchannels. The plasmon properties of thin metal films were investigated...
Presently, with the development of nanofabrications, patterning nanoparticles into monolayer attracts tremendous interests. In this work, a microfluidic-assisted nanoparticle monolayer patterning approach was proposed to produce noncontinuous patterns based on the well-known continuity equation in fluid mechanics. Soft-lithography used in this approach greatly reduced the cost and time of the fabrication...
The theoretical analysis, design and fabrication of PDMS-prism-coupled Kretschmann surface plasmon resonance (SPR) sensor were presented. The optical properties of very thin metal films have been evaluated by Fresnel analysis, with optical boundary conditions pertaining to the surface plasmon resonance at the gold/water and gold/air interface. The magnitude of the resonance, reflectance, full width...
Herein, a microfluidic-assisted dynamic assembly technique for close-packed nanoparticle monolayer patterning with high feature edge acuity and large-area uniformity is developed. Temporary PDMS microchannels are reversibly bonded to an oxidized silicon substrate whose surface is immobilized with 3- Aminopropyltriethoxysilane (APTES) to achieve a positive-potential surface. When the silica nanoparticle...
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