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MUC1 is a glycoprotein overexpressed in tumors as a hypoglycosylated form. A vaccine composed of a 100–amino acid peptide corresponding to five 20–amino acid long repeats, and SB-AS2 adjuvant, was tested in a phase I study for safety, toxicity, and ability to elicit or boost MUC1-specific immune responses. Patients with resected or locally advanced pancreatic cancer without prior chemotherapy or radiotherapy...
Two very permeable polymers, poly(1-trimethylsilyl-1-propyne) (PTMSP) and a random copolymer of tetrafluoroethylene and 2,2-bis(trifluoromethyl)-4,5-difluoro-1,3-dioxole (TFE/BDD), have very similar and large fractional free volumes (FFV), but very different permeabilities. Using atomistic models, cavity size (free volume) distributions determined by a combination of molecular dynamic and Monte Carlo...
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