Yasuharu Saito

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Endoscopic Submucosal Dissection Combined with the Placement of Biodegradable Stents for Recurrent Esophageal Cancer After Chemoradiotherapy

Yosuke Mochizuki, Yasuharu Saito, Toyohiko Tanaka, Norihisa Nitta, more

Journal of Gastrointestinal Cancer > 2012 > 43 > 2 > 324-328

We report a case of a patient with esophageal squamous cell carcinoma who presented with obstruction of the esophagus. On endoscopy, a central ulcerating lesion was found spreading to the anterior wall of the middle esophagus. Four courses of chemoradiation therapy successfully produced a complete response for 3 years. A recurrence occurred which consisted of a morphologically flat lesion that occupied...

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Magnified Endoscopy Combined with Narrow Band Imaging of Minimal Superficial Esophageal Neoplasia—Indicators to Differentiate Intraepithelial Neoplasias

Yosuke Mochizuki, Yasuharu Saito, Ayako Kobori, Hiromitsu Ban, more

Journal of Gastrointestinal Cancer > 2012 > 43 > 4 > 599-606

Purpose Clinical application of narrow band imaging facilitates diagnosis of esophageal neoplasia. However, no previous investigation has been conducted on magnifying endoscopy combined with narrow band imaging in detection of minimal superficial esophageal neoplasia, which is defined as neoplasia <10 mm in diameter. The aim of this retrospective study was to evaluate the usefulness of this combined...

article

Mo1464 The Efficacy and Safety of Threaded Biliary Plastic ”Inside-Stent” for Malignant Hilar Obstruction

Osamu Inatomi, Shigeki Bamba, Makoto Shioya, Yousuke Mochizuki, more

Gastrointestinal Endoscopy > 2011 > 73 > 4(S) > AB354

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Comparison of the fecal microbiota profiles between ulcerative colitis and Crohn’s disease using terminal restriction fragment length polymorphism analysis

Akira Andoh, Hirotsugu Imaeda, Tomoki Aomatsu, Osamu Inatomi, more

Journal of Gastroenterology > 2011 > 46 > 4 > 479-486

Background Terminal restriction fragment length polymorphism (T-RFLP) analysis is a powerful tool to assess the diversity of a microbial community. In this study, we performed T-RFLP analysis of the fecal microbiota from patients with ulcerative colitis (UC) and those with Crohn’s disease (CD). Methods Thirty-one patients with UC, 31 patients with CD, and 30 healthy individuals were enrolled. The...

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Pneumatosis coli with ulcerative colitis as a rare complication of colonoscopy

Shigeki Bamba, Tomoyuki Tsujikawa, Takao Saotome, Takafumi Okuno, more

Clinical Journal of Gastroenterology > 2010 > 3 > 5 > 233-236

Pneumatosis coli is a relatively rare condition characterized by the presence of gas in the submucosa or subserosa involving mainly the large intestine and, occasionally, the mesenteric attachments. We experienced two cases of pneumatosis coli with ulcerative colitis after colonoscopy that had different clinical courses. Case 1 showed submucosal pneumatosis coli and portal venous air. The air was...

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Interleukin-33 expression is specifically enhanced in inflamed mucosa of ulcerative colitis

Ayako Kobori, Yuhki Yagi, Hirotsugu Imaeda, Hiromitsu Ban, more

Journal of Gastroenterology > 2010 > 45 > 10 > 999-1007

Background Interleukin (IL)-33 is a cytokine belonging to the IL-1 family. IL-33 has been shown to elicit a Th2-like cytokine response in immune cells. In this study, we investigated IL-33 expression in the inflamed mucosa of patients with inflammatory bowel disease (IBD), and characterized the molecular mechanisms responsible for IL-33 expression in human colonic subepithelial myofibroblasts (SEMFs)...

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The multidrug-resistance protein 4 polymorphism is a new factor accounting for thiopurine sensitivity in Japanese patients with inflammatory bowel disease

Hiromistu Ban, Akira Andoh, Hirotsugu Imaeda, Ayako Kobori, more

Journal of Gastroenterology > 2010 > 45 > 10 > 1014-1021

Background Multidrug resistance protein 4 (MRP4) functions as an efflux pump of nucleoside monophosphate analogs, such as 6-mercaptopurine (6-MP) and 6-thioguanine nucleotide (6-TGN). A single-nucleotide polymorphism in human MRP4 (rs3765534) dramatically reduces MRP4 function and results in the intracellular accumulation of 6-TGN. In this study, we investigated the association between MRP4 G2269A...

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Re-evaluation of Histogenesis of Gastric Carcinomas: A Comparative Histopathological Study Between Helicobacter pylori-Negative and H. pylori-Positive Cases

Rie Kakinoki, Ryoji Kushima, Akiko Matsubara, Yasuharu Saito, more

Digestive Diseases and Sciences > 2009 > 54 > 3 > 614-620

We histopathologically re-evaluated the histogenesis of gastric carcinomas from comparative studies between Helicobacter pylori-positive and H. pylori-negative cases using the gastritis score from the Updated Sydney System. The incidence of H. pylori-negative gastric carcinomas was 3.11% (12/386); they are likely to develop in the fundic gland mucosa, and show a gastric phenotype by mucin immunohistochemistry...

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Single Balloon Enteroscopy: Is It Feasible?

Tomoyuki Tsujikawa, Yasuharu Saito, Yoshihide Fujiyma

Techniques in Gastrointestinal Endoscopy > 2008 > 10 > 2 > 62-65

Endoscopic surgery for the small intestine has attracted much attention in gastroenterology. We developed a novel type of enteroscopic technique, single balloon enteroscopy (SBE), for the examination of the small intestine. The SBE system consists of a dedicated endoscope, a sliding tube with a balloon, and an air controller to inflate or deflate the balloon of the overtube. During insertion of the...

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Novel Biodegradable Stents for Benign Esophageal Strictures Following Endoscopic Submucosal Dissection

Yasuharu Saito, Toyohiko Tanaka, Akira Andoh, Hideki Minematsu, more

Digestive Diseases and Sciences > 2008 > 53 > 2 > 330-333

The application of metallic stents for benign stenosis is limited due to long-term complications. We report here the results of the implantation of a novel biodegradable poly-l-lactic acid (PLLA) esophageal stent in two patients with benign esophageal stenosis after endoscopic submucosal dissection (ESD). Case 1 was a 64-year-old man who received ESD for an early squamous esophageal cancer in the...

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Chemoradiation Therapy Followed by Endoscopic Submucosal Dissection for Esophageal Cancer

Yasuharu Saito, Akira Andoh, Kazunori Hata, Tomoyuki Tsujikawa, more

Digestive Diseases and Sciences > 2008 > 53 > 12 > 3242-3245

We performed chemoradiation therapy (CRT) followed by an endoscopic submucosal dissection (ESD) for three patients with esophageal cancer. One patient refused surgery, and two patients were complicated with severe cardiopulmonary diseases. In all patients, CRT was effective in reducing tumor size, and the residual tumors were completely resected by ESD. All patients were recurrence-free for 6 months...

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Evaluation of mucin expression patterns in gastric borderline (group III) lesions

Hideki Minematsu, Yasuharu Saito, Rie Kakinoki, Akira Andoh, more

Journal of Gastroenterology > 2006 > 41 > 6 > 547-553

Background Recommendations for diagnosis and treatment of gastric borderline (group III) lesions remain controversial. We examined mucin expression patterns in endoscopically resected and forceps biopsy samples. Methods Sixty-three gastric lesions were histopathologically identified as belonging to group III on the basis of an endoscopic forceps biopsy. All of the patients underwent endoscopic resection,...

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Photoemission study of the U/Si(111) interface

Shin-ichi Fujimori, Yasuharu Saito, Ken-ichirou Yamaki, Tetsuo Okane, more

Surface Science > 2000 > 444 > 1-3 > 180-186

The electronic and geometric structures of thin uranium overlayers deposited on a clean Si(111)-(7×7) surface have been studied by X-ray photoelectron spectroscopy (XPS) and low-energy electron diffraction (LEED). Three different stages of interaction between the deposited uranium and the silicon substrate are found, depending on the uranium coverage. A transition from localized to delocalized U5f...

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The U 5f states in the heavy fermion uranium compound UPd2Al3, studied by resonant and X-ray photoelectron spectroscopy

Shin-ichi Fujimori, Yasuharu Saito, Masaharu Seki, Koji Tamura, more

Journal of Electron Spectroscopy and Related Phenomena > 1999 > 101-103 > Complete > 439-442

We have measured the X-ray photoemission and X-ray bremsstrahlung isochromat spectra of UPd ₂ Al ₃ , and compared with the results of the band structure calculation. The near E _F part of the spectra are well reproduced by the calculated U 5f density of states, although the experimental spectra are broader than the calculations. These results suggest that the band structure...

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The electronic structure of U/Si(100), studied by X-ray photoelectron spectroscopy

Shin-ichi Fujimori, Yasuharu Saito, Ken-ichiro Yamaki, Tetsuo Okane, more

Journal of Electron Spectroscopy and Related Phenomena > 1998 > 88-91 > Complete > 631-635

We have studied the electronic and geometric structure of thin uranium layers deposited on a clean Si(100)2 × 1 surface through X-ray photoelectron spectroscopy (XPS) and low energy electron diffraction (LEED). A formation of reacted and disordered interfaces was observed by the deposition of uranium at room temperature. Annealing of the substrate higher than 700°C results in drastic changes in the...

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X-ray photoelectron spectroscopy study of uranium compounds

Shin-ichi Fujimori, Yasuharu Saito, Ken-ichiro Yamaki, Yoshinori Haga, more

Journal of Electron Spectroscopy and Related Phenomena > 1998 > 88-91 > Complete > 353-356

We have performed X-ray photoelectron spectroscopy studies on three heavy-fermion superconductors UPt ₃ , UNi ₂ Al ₃ and UPd ₂ Al ₃ , putting emphasis on the analysis of their core-level spectra. The results are compared with the spectra of the itinerant U 5f compounds URh ₃ . The comparison of core-level spectra of these compounds suggests that the...

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A photoemission study of ultrathin uranium layers on noble metals

Shin-ichi Fujimori, Yasuharu Saito, Takeo Ejima, Noriaki Sato, more

Journal of Electron Spectroscopy and Related Phenomena > 1996 > 78 > 155-158

The core levels and valence states of ultrathin uranium layers on gold and nickel substrates have been studied using XPS. Uranium coverage was less than 2.8 Å which corresponds to less than one monolayer. The spectral features are very similar to those of intermetallic compounds of uranium and gold or nickel. This indicates intermixing of deposited uranium with the substrates, at room temperature...

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Search results for: Yasuharu Saito

Endoscopic Submucosal Dissection Combined with the Placement of Biodegradable Stents for Recurrent Esophageal Cancer After Chemoradiotherapy

Magnified Endoscopy Combined with Narrow Band Imaging of Minimal Superficial Esophageal Neoplasia—Indicators to Differentiate Intraepithelial Neoplasias

Mo1464 The Efficacy and Safety of Threaded Biliary Plastic ”Inside-Stent” for Malignant Hilar Obstruction

Comparison of the fecal microbiota profiles between ulcerative colitis and Crohn’s disease using terminal restriction fragment length polymorphism analysis

Pneumatosis coli with ulcerative colitis as a rare complication of colonoscopy

Interleukin-33 expression is specifically enhanced in inflamed mucosa of ulcerative colitis

The multidrug-resistance protein 4 polymorphism is a new factor accounting for thiopurine sensitivity in Japanese patients with inflammatory bowel disease

Re-evaluation of Histogenesis of Gastric Carcinomas: A Comparative Histopathological Study Between Helicobacter pylori-Negative and H. pylori-Positive Cases

Single Balloon Enteroscopy: Is It Feasible?

Novel Biodegradable Stents for Benign Esophageal Strictures Following Endoscopic Submucosal Dissection

Chemoradiation Therapy Followed by Endoscopic Submucosal Dissection for Esophageal Cancer

Evaluation of mucin expression patterns in gastric borderline (group III) lesions

Photoemission study of the U/Si(111) interface

The U 5f states in the heavy fermion uranium compound UPd2Al3, studied by resonant and X-ray photoelectron spectroscopy

The electronic structure of U/Si(100), studied by X-ray photoelectron spectroscopy

X-ray photoelectron spectroscopy study of uranium compounds

A photoemission study of ultrathin uranium layers on noble metals

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