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DEP-domain containing 5 (DEPDC5), encoding a repressor of the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway, has recently emerged as a major gene mutated in familial focal epilepsies and focal cortical dysplasia. Here we established a global knockout rat using TALEN technology to investigate in vivo the impact of Depdc5-deficiency. Homozygous Depdc5−/− embryos died from embryonic...
We present in vivo dynamic-clamp electrophysiological recordings to characterize the influences of shunting inhibition and the potassium current IBK on the input–output (I/O) transfer function of cortical neurons, in response to both artificial (injected current or conductance) and functional visual stimuli. In comparison to previous experimental and theoretical studies, we find that realistic...
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