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AbstractGroups of male Sprague-Dawley rats were administered orally the following chlorinated dibenzo-p-dioxins (CDDs) in corn oil/acetone (95/5; v/v): 3060g/kg 2,3,7,8-tetrachlorodibenzo-dioxin (tetra-CDD), 160270g/kg 1,2,3,7,8-pentachlorodibenzo-p-dioxins (penta-CDD), 6301249g/kg 1,2,3,4,7,8-hexachlorodibenzo-p-dioxin (hexa-CDD) and 50008000 g/kg 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin (hepta-CDD)...
AbstractThe aim of this study was to examine the acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in a rat strain other than the Sprague-Dawley (S-D) rat, for which most of our data have been generated thus far. Doses for the biochemical study were selected based on an acute range-finding study, which indicated that Long-Evans (L-E) rats are somewhat less susceptible to TCDD toxicity than...
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