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The traditional tris(bipyridine)ruthenium(II) complex suffers from the notorious aggregation‐caused quenching effect, which greatly compromises its electrochemiluminescence (ECL) efficiency, thus hindering further applications in biosensing and clinical diagnosis. Here, the ultrathin tetraphenylethylene‐active tris(bipyridine)ruthenium(II) derivative nanosheets (abbreviated as Ru‐TPE NSs) are synthesized...
Solar energy‐driven water evaporation is a promising sustainable strategy to purify seawater and contaminated water. However, developing solar evaporators with high water evaporation rates and excellent salt resistance still faces a great challenge. Herein, inspired by the long‐range ordered structure and water transportation capability of lotus stem, a biomimetic aerogel with vertically ordered channels...
Quantifying the binding kinetics and affinities of protein–small molecule interactions is critical for biomarker validation, drug discovery, and deep understanding of various biological processes at the molecular‐scale. Novel approaches are demanded as most common label‐free techniques are mass‐sensitive, which are not suitable for the detection of small molecule interactions. Here, an optical imaging...
Carbonized Polymer Dots
In article number 2106863, Yeqing Chen, Ping Liang, Jun Lin, and co‐workers synthesize transition metal Mn ions doped in the form of covalent Mn–O bonds. The Mn–O bridge accelerates the electron flow between adjacent sp2 domains and enhances the electron transport in the Mn–carbonized polymer dots, thus improving the photoluminescence quantum yield and catalytic performance...
Carbonized polymer dots (CPDs) have received tremendous attention during the last decade due to their excellent fluorescent properties and catalytic performance. Doping CPDs with transition metal atoms accelerates the local electron flow in CPDs and improves the fluorescent properties and catalytic performance of the CPDs. However, the binding sites and the formation mechanisms of the transition‐metal‐atom‐doped...
Cancer stem cells (CSCs) possess a high degree of plasticity, constituting a formidable challenge to identify and screen CSCs in situ with outstanding specificity and sensitivity. To overcome this limitation, a self‐assembled heterodimer consisting of clustered regularly interspaced short palindromic repeats/Cas12a (named A‐CCA) linkage is designed for in situ identification and screening of gastric...
Although chemotherapy and photothermal therapy are widely used to combat cancer, their efficacy is often limited by multidrug resistance. Small interfering RNAs (siRNAs) have ability to suppress the expression of target genes, which has been extensively employed for combating the multidrug resistance to chemodrugs and hyperthermia in cancer therapy. However, efficient delivery of siRNAs along with...
During photodynamic therapy (PDT), severe hypoxia often occurs as an undesirable limitation of PDT owing to the O2‐consuming photodynamic process, compromising the effectiveness of PDT. To overcome this problem, several strategies aiming to improve tumor oxygenation are developed. Unlike these traditional approaches, an opposite method combining hypoxia‐activated prodrug and PDT may provide a promising...
In article number 1803428, Jian Lin and co‐workers report the discovery of a novel self‐assembled metal protein nanoparticle, designated GST‐MT‐3, which targets the mitochondria of cancer cells within 30 min in vitro and rapidly accumulates in tumors within 1 h in vivo. The little men carrying the bombs represent GST‐MT3 protein nanoparticles loading the cobalt ions. Through the blood vessels they...
Self‐assembled protein nanoparticles have attracted much attention in biomedicine because of their biocompatibility and biodegradability. Protein nanoparticles have become widely utilized as diagnostic or therapeutic agents for various cancers. However, there are no reports that protein nanoparticles can specifically target mitochondria. This targeting is desirable, since mitochondria are critical...
In vivo mineralization is a multistep process involving mineral‐protein complexes and various metastable compounds in vertebrates. In this complex process, the minerals produced in the mitochondrial matrix play a critical role in initiating extracellular mineralization. However, the functional mechanisms of the mitochondrial minerals are still a mystery. Herein, an in vitro enzymatic reaction strategy...
In article number 1804321, Ying‐Jie Zhu, Zheng‐Dong Cai, Feng Chen, and co‐workers report an enzymatic reaction strategy for the generation of biomimic nanominerals. The results provide in vitro evidence for the effect of ATP on the formation and stabilization of the biomineral, and demonstrate a potential strategy for the preparation of the biomimic mineral for treating bone related diseases.
Efficient utilization of abundant solar energy for clean water generation is considered a sustainable and environment friendly approach to mitigate the global water crisis. For this purpose, this study reports a flexible fire‐resistant photothermal paper by combining carbon nanotubes (CNTs) and fire‐resistant inorganic paper based on ultralong hydroxyapatite nanowires (HNs) for efficient solar energy‐driven...
Intracellular microRNAs imaging based on upconversion nanoprobes has great potential in cancer diagnostics and treatments. However, the relatively low detection sensitivity limits their application. Herein, a lock‐like DNA (LLD) generated by a hairpin DNA (H1) hybridizing with a bolt DNA (bDNA) sequence is designed, which is used to program upconversion nanoparticles (UCNPs, NaYF4@NaYF4:Yb, Er@NaYF...
Here, a sensitive and universal noncoding RNA (ncRNA) upconversion sensing nanoplatform is developed. Gold nanoparticles bearing one hairpin DNA (Hp) molecule are conjugated to the linker DNA modified NaYF4:Yb, Er@NaYF4 upconversion nanoparticles by DNA hybridization, leading to quenching of the upconversion emission through fluorescence resonance energy transfer. A signal DNA (SDNA) sequence is designed...
In article number 1703858, Xingcai Wu, Jun‐Jie Zhu, and co‐workers report a universal and sensitive upconversion sensing nanoplatform for detecting tumor‐related non‐coding RNA. The sensitivity of the probe is improved by tuning the number of DNA units on the gold nanoparticles, and an exonuclease III‐assisted target cycling amplification strategy improves the sensitivity and achieves the universality...
A noble‐metal‐free electrocatalyst is fabricated via in situ formation of nanocomposite of nitrogen‐doped graphene quantum dots (NGQDs) and Ni3S2 nanosheets on the Ni foam (Ni3S2‐NGQDs/NF). The resultant Ni3S2‐NGQDs/NF can serve as an active, binder‐free, and self‐supported catalytic electrode for direct water splitting, which delivers a current density of 10 mA cm−2 at an overpotential of 216 mV...
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