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Any technical object is defined by a structure and certain related properties, together with a function and a way of making it. A biological object is thus a biochemical structure, either organic or organically based, which possesses one or more biological properties (recognition, structure, transformation, etc.), which carries out a specific function, and which is produced by a biological process...
DOT-IMAGER a réuni des physiciens, des chimistes et des biologistes des secteurs académique et industriel dans un programme de développement de nouveaux traceurs multimodaux spécifiques et de leurs techniques d’imagerie associées. Ont participé au projet deux laboratoires du CEA (SHFJ et SMMCB), le laboratoire de spectroscopie en lumière polarisée de l’ESPCI, et la société Mauna Kea Technologies (MKT),...
Les aptamères sont des oligonucléotides sélectionnés à partir d'une banque aléatoire de séquences selon leur aptitude à reconnaître une cible. Des aptamères présentant des affinités et spécificités comparables à celles des anticorps pour des molécules variées (acides aminés, antibiotiques, motifs ARN ou ADN, protéines) ont été obtenus avec, dans bien des cas, un effet inhibiteur. Un aptamère inhibant...
Oligonucleotides are multifunctional molecules which can interfere with gene expression by different mechanism such as antisense, RNA interference, ribozymes, etc. For most in vivo diagnostic and therapeutic applications, oligonucleotides need to be delivered to the intracellular compartment of a specific organ, a difficult task which limits considerably their use. However, aptamer oligonucleotides...
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