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The shedding of ectodomains is a crucial mechanism in many physiological and pathological events. A disintegrin and metalloprotease‐17 (ADAM17) is a key sheddase involved in essential processes, such as development, regeneration, and immune defense. ADAM17 exists in two conformations which differ in their disulfide connection in the membrane‐proximal domain (MPD). Protein‐disulfide isomerases (PDIs)...
Histones are abundant nuclear core proteins that are present in all eukararyotes and are responsible for linking chromosomes and packaging them into tight chromatin aggregates. The histone H2A, H2B, and H3 genes and a partial sequence of the histone H4 gene from Plasmodium falciparum have been previously identified and share a high level of nucleotide sequence identity. In this study, we compare the...
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