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There have been many advances in the processes of product design and development over the last 25 years. Some of the advances have been in technology support tools and some have been in the product realization processes themselves as recognition of the technology capabilities develops and matures and incorporates the business practices that guide the development practices. These advances are briefly...
In this paper, we consider an actual industrial warehouse order picking problem where goods are stored at multiple locations and the pick location of goods can be selected dynamically in near real time. We solve the problem using an intelligent agent-based model. The modeling framework is between the two extremes of hierarchical and heterarchical frameworks. It recognizes that horizontal as well as...
The translocation of phospholipids across the plasma membrane has been widely documented as one of the earliest measurable biochemical events of apoptosis. Using fluorescently labelled annexin V, which preferentially binds phosphatidylserine (PS) in the presence of Ca2+, the externalization of PS can be measured and apoptosis quantified using flow cytometry. Conventional detection methods utilizing...
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