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Loss-of-function mutations in the DJ-1 gene account for an autosomal recessive form of Parkinson's disease (PD). To investigate the physiological functions of DJ-1 in vivo, we generated DJ-1 knockout (DJ-1 −/− ) mice. Younger (<1 year) DJ-1 −/− mice were hypoactive and had mild gait abnormalities. Older DJ-1 −/− , however, showed decreased body weight and grip strength and...
Mutations in DJ-1 cause inherited Parkinson’s disease (PD) in several families. The normal function of DJ-1 is unknown, but mice lacking DJ-1 exhibit a deficit in dopaminergic signaling in the striatum. Since the hippocampus contains relatively high levels of DJ-1, and PD patients are often cognitively impaired, we evaluated the effects of DJ-1 deficiency on the plasticity of hippocampal CA1 synapses...
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