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Rationale In recent years, an increasing body of evidence points to the involvement of the glutamatergic system and specifically the glutamatergic ionotropic N-methyl-d-aspartate (NMDA) receptor in the pathophysiology of obsessive–compulsive disorder (OCD). Objectives To test the role of NMDA receptors in compulsive behavior using the signal attenuation rat model of OCD. In this model, ‘compulsive’...