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Novel derivatives based on calix[4]arene and ibuprofen were prepared. Physicochemical analysis methods were used to identify these compounds. Studies of their anti-inflammatory actions in a carrageenan edema model showed that these substances had greater anti-inflammatory effects than ibuprofen.
The results of experimental investigations of the anti-inflammatory effect of ultrasound on the inflammatory process on a rat model of carrageenan-induced edema of the hind limb are given. The technique used in the experiment showing ultrasound exposure parameters and how to control the characteristics of inflammatory process is described. The anti-inflammatory effect of ultrasound is established.
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