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Recombinant activated factor VII (rFVIIa) is indicated in bleeding patients when a life-threatening haemorrhage occurs. Prothrombin complex concentrates (PCCs) are also used for this indication in several countries, without any evidence-based rationale. Our objective was to compare the efficacy and safety of PCC and rFVIIa in a model of bleeding and thrombosis in haemodiluted rabbits. Forty-eight...
Résumé Les objectifs de l’évaluation gériatrique globale sont de décrire réellement les patients âgés atteints de cancer, de diagnostiquer et traiter leurs comorbidités et d’adapter les traitements anticancéreux à l’état réel de ces patients plutôt qu’à leur âge. Des essais cliniques ont montré la valeur pronostique de paramètres gériatriques comme la comorbidité. La validation de grilles de dépistage...
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