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Exposure of cells to ionizing radiation (IR) or tumor necrosis factor-a(TNF-a) results in the stimulation of the DNA binding activities oftranscription factors, AP-1 and NF-kB. HVH1/CL100, a dual specificityprotein phosphatase, may attenuate the AP-1 response by dephosphorylating akey upstream element, mitogen-activated protein kinase (MAPK). The membersof IkB family of proteins regulate the NF-kB...