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The cytoskeleton of cardiac myocytes consists of actin, the intermediate filament desmin and of α- and β-tubulin that form the microtubules by polymerization. Vinculin, talin, dystrophin and spectrin represent a separate group of membrane-associated proteins. In numerous experimental studies, the role of cytoskeletal alterations especially of microtubules and desmin, in cardiac hypertrophy and failure...
We present a classification of the proteins of the cardiomyocyte based on structural and functional properties of the various components of this cell. The following protein families are categorized: 1) the contractile proteins, responsible for the contractile properties; 2) the sarcomeric skeleton, including titin, α-actinin, myomesin, M-protein, and C-protein, that keeps the contractile filaments...
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