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Leukocyte adhesion to vascular endothelial cells is an essential step in the development of inflammatory diseases. We have searched for inhibitors of leukocyte-endothelial cell adhesion that could be used as anti-inflammatory drugs and found that bruceine B (0.2 μg/ml; 0.44 μM) inhibited human neutrophil or T cell adhesion to tumor necrosis factor-α (TNF) stimulated human umbilical vein endothelial...