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Although platelets lack nuclei, they are capable of de novo protein synthesis. We speculate that key platelet receptors are involved in the regulation of this process, and the changes in their number indicate the de novo protein synthesis in platelets. The object of our study was native platelets obtained from healthy donors. Using flow cytometry and Western blot, we determined the number of GP IIb-IIIa...
Cerebrovascular diseases are the second leading cause of mortality and are one of the most important medical and social problems. After the damage of the vascular wall endothelial cells secrete von Willebrand factor that binds to its receptor, glycoprotein GP Ib-V-IX, on the platelet surface. There are two known GP Ibα gene polymorphisms, Thr145Met and T(−5)C, associated with the risk of the development...
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