Search results for: Florian Schuetz

Items from 1 to 20 out of 32 results

article

Efficacy and safety of everolimus plus exemestane in patients with hormone receptor‐positive, HER‐2‐negative advanced breast cancer: Results from the open‐label, multicentre, non‐interventional BRAWO study

Diana Lüftner, Florian Schuetz, Andreas Schneeweiss, Andreas Hartkopf, more

International Journal of Cancer > 155 > 1 > 128 - 138

BRAWO, a real‐world study, assessed the efficacy, quality of life (QoL) and safety of EVE + EXE in postmenopausal women with HR+/HER2– advanced breast cancer (ABC) in routine clinical practice. Postmenopausal women with HR+/HER2‐ABC with recurrence or progression after a NSAI were included. Primary Observation parameters included the evaluation of the effectiveness of EVE + EXE. A multivariate‐analysis...

article

Exam preparatory course for the 2nd part of the German medical examination in obstetrics and gynecology – a potential tool for the recruitment of new residents during the occupational decision process before the practical year?

Fabian Riedel, Maximilian Riedel, Alexander Freis, Joerg Heil, more

BMC Medical Education > 2019 > 19 > 1 > 1-9

Background The “Second Stage of the Physician Exam” at the end of the 5th year of medical school in Germany is the final step before the “Practical Year.” An exam preparatory class can cover the complete content of Obstetrics and Gynecology (OB/GYN) in two days. We raise the question of whether such training might promote students’ interest in the given specialty during occupational decision making...

article

Implementation of a novel efficacy score to compare sealing and cutting devices in a porcine model

Lea Brecht, Markus Wallwiener, Sarah Schott, Christoph Domschke, more

Surgical Endoscopy > 2018 > 32 > 2 > 1002-1011

Background In general surgery, minimally invasive laparoscopic procedures have been steadily increasing over the last decade. The application of advanced bipolar and ultrasonic energy devices for sealing and cutting of blood vessels plays a vital role in routine clinical procedures. The advantages of energy-based instruments are enhanced sealing capability combined with both fast sealing time and...

article

Inter-rater reliability and double reading analysis of an automated three-dimensional breast ultrasound system: comparison of two independent examiners

Anna Maier, Joerg Heil, Anna Lauer, Aba Harcos, more

Archives of Gynecology and Obstetrics > 2017 > 296 > 3 > 571-582

Purpose Breast ultrasound could be a valuable tool complementary to mammography in breast cancer screening. Automated 3D breast ultrasound (ABUS) addresses challenges of hand-held ultrasound and could allow double reading analysis of ultrasound images. This trial assesses the inter-rater reliability and double reading analysis of an ABUS system. Methods To assess the reproducibility and diagnostic...

article

Use of complementary and integrative medicine among German breast cancer patients: predictors and implications for patient care within the PRAEGNANT study network

Carlo Fremd, Carolin C. Hack, Andreas Schneeweiss, Geraldine Rauch, more

Archives of Gynecology and Obstetrics > 2017 > 295 > 5 > 1239-1245

Purpose The present study aims to analyze a cohort of advanced breast cancer patients in Germany to assess their interest in complementary and alternative medicine (CAM) and patient’s use of most frequent CAM methods. Patients and methods Based on the PREGNANT real-time breast cancer registry which is a multicenter study in Germany, questionnaires of 580 patients with advanced breast cancer were...

article

Tumor specific regulatory T cells in the bone marrow of breast cancer patients selectively upregulate the emigration receptor S1P1

Anchana Rathinasamy, Christoph Domschke, Yingzi Ge, Hans-Henning Böhm, more

Cancer Immunology, Immunotherapy > 2017 > 66 > 5 > 593-603

Regulatory T cells (Treg) hamper anti-tumor T-cell responses resulting in reduced survival and failure of cancer immunotherapy. Among lymphoid organs, the bone marrow (BM) is a major site of Treg residence and recirculation. However, the process governing the emigration of Treg from BM into the circulation remains elusive. We here show that breast cancer patients harbour reduced Treg frequencies in...

article

Impact of reproductive factors on breast cancer subtypes in postmenopausal women: a retrospective single-center study

Alexandra Au, Mona Klotzbuecher, Lorenz Uhlmann, Mark Boudewijns, more

Archives of Gynecology and Obstetrics > 2017 > 295 > 4 > 971-978

Purpose Some reproductive factors are well-known general risk factors for breast cancer (BC). On the other hand, BC subtypes also have a high prognostic value. Correlations, however, that link these risk factors to the development of a particular one of the different BC subtypes are still poorly understood. The primary objective of our study was to assess the influence of different reproductive factors...

article

Can a pathological complete response of breast cancer after neoadjuvant chemotherapy be diagnosed by minimal invasive biopsy?

Joerg Heil, Benedikt Schaefgen, Peter Sinn, Hannah Richter, more

European Journal of Cancer > 2016 > 69 > C > 142-150

This study aimed to explore the ability of a minimal invasive biopsy to diagnose a pathological complete response (pCR = ypT0) in the breast.Ultrasound-guided, vacuum-assisted, minimal invasive biopsy (VAB) was performed in 50 patients after neoadjuvant chemotherapy and before breast surgery. Negative predictive values (NPV) and false negative rates (FNR) to predict a pCR in surgical specimen were...

article

Patient-reported outcomes (PRO) focused on adverse events (PRO-AEs) in adjuvant and metastatic breast cancer: clinical and translational implications

Stefan Stefanovic, Markus Wallwiener, Uros Karic, Christoph Domschke, more

Supportive Care in Cancer > 2017 > 25 > 2 > 549-558

Purpose The capture of adequate treatment outcomes and quality of life (QOL) of advanced breast cancer patients in clinical routine represents a great challenge. Patient-reported outcomes (PROs) are data elements directly reported by patients about experiences with care, including symptoms, functional status, or quality of life. There is growing interest in the medical community for the evaluation...

article

Exam preparation course in obstetrics and gynecology for the German Medical State Examination: proof of concept and implications for the recruitment of future residents

Fabian Riedel, Carlo Fremd, Patrik Tabatabai, Katharina Smetanay, more

Archives of Gynecology and Obstetrics > 2016 > 294 > 6 > 1235-1241

Objectives Today´s written part of the medical state examination requires students to retrieve a comprehensive amount of knowledge in a limited period of time. Therefore, the main study objectives were to implement and to evaluate a two-day exam preparation course for the German Medical State Examination in obstetrics and gynecology. The project evaluation focused on acceptability, satisfaction and...

article

Do Patients After Reexcision Due to Involved or Close Margins Have the Same Risk of Local Recurrence as Those After One-Step Breast-Conserving Surgery?

André Hennigs, Valerie Fuchs, Hans-Peter Sinn, Fabian Riedel, more

Annals of Surgical Oncology > 2016 > 23 > 6 > 1831-1837

Purpose To explore whether patients after a reexcision due to involved or close margins have the same risk of local recurrence (LR) than those after a one-step breast-conserving surgery (BCS); to learn whether the presence of residual cancer in the reexcision specimen influences the probability of LR. Methods We reviewed demographic, clinical, radiologic, and pathologic records of a cohort of...

article

Disseminated Tumor Cells in the Bone Marrow of Patients with Operable Primary Breast Cancer: Prognostic Impact in Immunophenotypic Subgroups and Clinical Implication for Bisphosphonate Treatment

Stefan Stefanovic, Ingo Diel, Peter Sinn, Stefan Englert, more

Annals of Surgical Oncology > 2016 > 23 > 3 > 757-766

Background Disseminated tumor cells (DTC) in the bone marrow (BM) of primary breast cancer (BC) patients are a promising surrogate marker of micrometastatic spread and an independent predictor of poor prognosis for disease-free survival (DFS) and overall survival (OS). The present study aims to analyze DTCs as an independent prognostic factor for DFS/OS in tumor biology and bisphosphonate treatment...

article

Efficacy and toxicity profile of pegylated liposomal doxorubicin in patients with advanced ovarian cancer

Christine Mayer, Janina Brucker, Florian Schuetz, Christoph Domschke, more

Archives of Gynecology and Obstetrics > 2016 > 294 > 1 > 123-129

Background The prognosis of patients with non-platinum-sensitive recurrent ovarian cancer is poor. There is a need for salvage therapies with anti-tumor activity and acceptable toxicity for maintaining quality of life. Pegylated liposomal doxorubicin (PLD, Caelyx^®) is a promising drug fulfilling these demands. We present retrospective data of patients with advanced epithelial ovarian cancer (EOC)...

article

Breast cancer presentation and therapy in migrant versus native German patients: contrasting and convergent data of a retrospective monocentric study

Alexandra von Au, Ulrike Weiler, Stefan Stefanovic, Markus Wallwiener, more

Archives of Gynecology and Obstetrics > 2016 > 294 > 1 > 145-152

Purpose The aim of this study was to identify differences between breast cancer patients with and without migrant background in Germany, especially differences concerning patient characteristics, tumor biology, diagnostics, therapy, and oncological outcome. Patients and methods In 99 breast cancer patients (composed of 50 native, randomly selected Germans and 49 consecutively selected immigrants...

article

Predictors of early poor aesthetic outcome after breast‐conserving surgery in patients with breast cancer: Initial results of a prospective cohort study at a single institution

Eva Foersterling, Michael Golatta, Andre Hennigs, Sophie Schulz, more

Journal of Surgical Oncology > 110 > 7 > 801 - 806

Background and objectives The aim of this study was to explore features of patients reporting early poor aesthetic outcome after simple breast‐conserving surgery.Methods We prospectively evaluated 709 patients shortly after breast‐conserving surgery. Aesthetic outcome was measured by aesthetic status scores of the Breast Cancer Treatment Outcome Scale. Clinical, surgical, and pathologic variables...

article

Adoptive immunotherapy of metastatic breast cancer: present and future

Stefan Stefanovic, Florian Schuetz, Christof Sohn, Philipp Beckhove, more

Cancer and Metastasis Reviews > 2014 > 33 > 1 > 309-320

Breast cancer is a systemic disease with a primarily local component. Besides surgical resection and irradiation of the locoregional tumor setting, central therapeutic aim is the elimination of disseminated micrometastatic tumor cells using cytostatic and/or hormonal treatment. Nevertheless, in the course of time a majority of patients suffer from systemic recurrence in the form of distant metastases...

article

Pooled analysis of the prognostic relevance of progesterone receptor status in five German cohort studies

Jessica Salmen, Julia Neugebauer, Peter A. Fasching, Lothar Haeberle, more

Breast Cancer Research and Treatment > 2014 > 148 > 1 > 143-151

The progesterone receptor (PR) has been increasingly well described as an important mediator of the pathogenesis and progression of breast cancer. The aim of this study was to assess the role of PR status as a prognostic factor in addition to other well-established prognostic factors. Data from five independent German breast cancer centers were pooled. A total of 7,965 breast cancer patients were...

article

Prediction of underestimated invasiveness in patients with ductal carcinoma in situ of the breast on percutaneous biopsy as rationale for recommending concurrent sentinel lymph node biopsy

Sophie Schulz, Peter Sinn, Michael Golatta, Geraldine Rauch, more

The Breast > 2013 > 22 > 4 > 537-542

To develop a model to predict invasion and improve the indication of concurrent sentinel lymph node biopsy (SLNB) for patients with ductal carcinoma in situ (DCIS) on minimally invasive biopsy.We evaluated the data of 205 patients with DCIS in minimally invasive biopsy specimens. Clinical, radiological and histological variables were assessed in order to identify predictors of invasive carcinoma in...

article

Interobserver reliability of automated breast volume scanner (ABVS) interpretation and agreement of ABVS findings with hand held breast ultrasound (HHUS), mammography and pathology results

Michael Golatta, Dorothea Franz, Aba Harcos, Hans Junkermann, more

European Journal of Radiology > 2013 > 82 > 8 > e332-e336

Handheld breast ultrasound (HHUS) lacks standardization and reproducibility. The automated breast volume scanner (ABVS) could overcome this limitation. To analyze the interobserver reliability of ABVS and the agreement with HHUS, mammography and pathology is the aim of this study.All 42 study participants (=84 breasts) received an ABVS examination in addition to the conventional breast diagnostic...

article

Bone marrow microenvironment in cancer patients: immunological aspects and clinical implications

Stefan Stefanovic, Florian Schuetz, Christof Sohn, Philipp Beckhove, more

Cancer and Metastasis Reviews > 2013 > 32 > 1-2 > 163-178

The bone marrow (BM) of cancer patients is considered an essential secondary lymphoid organ with substantial impact on tumor cell dissemination and tumor–immune responses. Recent advances in the understanding of BM/primary tumor crosstalk, homing processes, premetastatic niche formation, tumor cell dormancy, and ultimately, identification of the BM micromilieu cytokines, chemokines, and growth factors...

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INFONA - science communication portal

Search results for: Florian Schuetz

Efficacy and safety of everolimus plus exemestane in patients with hormone receptor‐positive, HER‐2‐negative advanced breast cancer: Results from the open‐label, multicentre, non‐interventional BRAWO study

Exam preparatory course for the 2nd part of the German medical examination in obstetrics and gynecology – a potential tool for the recruitment of new residents during the occupational decision process before the practical year?

Implementation of a novel efficacy score to compare sealing and cutting devices in a porcine model

Inter-rater reliability and double reading analysis of an automated three-dimensional breast ultrasound system: comparison of two independent examiners

Use of complementary and integrative medicine among German breast cancer patients: predictors and implications for patient care within the PRAEGNANT study network

Tumor specific regulatory T cells in the bone marrow of breast cancer patients selectively upregulate the emigration receptor S1P1

Impact of reproductive factors on breast cancer subtypes in postmenopausal women: a retrospective single-center study

Can a pathological complete response of breast cancer after neoadjuvant chemotherapy be diagnosed by minimal invasive biopsy?

Patient-reported outcomes (PRO) focused on adverse events (PRO-AEs) in adjuvant and metastatic breast cancer: clinical and translational implications

Exam preparation course in obstetrics and gynecology for the German Medical State Examination: proof of concept and implications for the recruitment of future residents

Do Patients After Reexcision Due to Involved or Close Margins Have the Same Risk of Local Recurrence as Those After One-Step Breast-Conserving Surgery?

Disseminated Tumor Cells in the Bone Marrow of Patients with Operable Primary Breast Cancer: Prognostic Impact in Immunophenotypic Subgroups and Clinical Implication for Bisphosphonate Treatment

Efficacy and toxicity profile of pegylated liposomal doxorubicin in patients with advanced ovarian cancer

Breast cancer presentation and therapy in migrant versus native German patients: contrasting and convergent data of a retrospective monocentric study

Predictors of early poor aesthetic outcome after breast‐conserving surgery in patients with breast cancer: Initial results of a prospective cohort study at a single institution

Adoptive immunotherapy of metastatic breast cancer: present and future

Pooled analysis of the prognostic relevance of progesterone receptor status in five German cohort studies

Prediction of underestimated invasiveness in patients with ductal carcinoma in situ of the breast on percutaneous biopsy as rationale for recommending concurrent sentinel lymph node biopsy

Interobserver reliability of automated breast volume scanner (ABVS) interpretation and agreement of ABVS findings with hand held breast ultrasound (HHUS), mammography and pathology results

Bone marrow microenvironment in cancer patients: immunological aspects and clinical implications

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