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Background
TMEM16A, a Ca‐activated Cl channel, regulates various physiological functions such as mucin secretion. However, the role of TMEM16A in hyper‐secretion in asthma is not fully understood.
Objective
The aim of this study is to evaluate Cl ion transport via TMEM16A and determine the localization of TMEM16A in a guinea‐pig asthma model.
Methods
Guinea‐pigs were sensitized with ovalbumin...
Th2 cytokines play an important part in the pathogenesis of asthma. Our aim was to study the effect of suplatast tosilate, a selective Th2 cytokine inhibitor, on asthma control and asthma exacerbations during reduction of inhaled corticosteroid dose in patients with steroid-dependent asthma.85 patients with moderate to severe asthma taking high doses (⩾1500 μg per day) of inhaled beclometasone dipropionate,...
. To determine whether functional atypical β-adrenoceptors (β3-adrenoceptors) are present in pulmonary vascular smooth muscle, we studied isolated canine pulmonary arterial rings under isometric conditions in vitro. Addition of β-adrenoceptor agonists produced a concentration-dependent relaxation of noradrenaline-precontracted tissues, a rank order potency being isoproterenol (1) > salbutamol...
Abstract. To determine whether functional atypical -adrenoceptors (3-adrenoceptors) are present in pulmonary vascular smooth muscle, we studied isolated canine pulmonary arterial rings under isometric conditions in vitro. Addition of -adrenoceptor agonists produced a concentration-dependent relaxation of noradrenaline-precontracted tissues, a rank order potency being isoproterenol (1) salbutamol (0...
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