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The Principal Component Analysis (PCA) of the tumor fre- quency distribution across Europe highlighted the existence of a strong and reliable deterministic structure organizing the spatial variability of the relative frequency of the different tumors. The analysis highlighted 5 principal “macrocauses” organizing the spatial variability of tumor in- cidences for both sexes. These “macrocauses” were...
The project Detection of Germ Cell Mutagens was designed with three major goals: (1) Detection and characterization of germ-cell mutagens; (2) standardization and validation of new germ-cell tests; and (3) development of a data base on germ-cell mutagenicity. All three goals were achieved. The classical germ-cell tests were applied to characterize the genetic effects of acrylamide (AA), 1,3-butadiene...
Although aneuploidy makes a significant contribution to both somatic and inherited disease the mechanisms by which environmental chemicals may induce numerical chromosome aberrations are only poorly defined. The European Union Project was aimed to further our understanding of those chemical interactions with the components of the mitotic and meiotic cell division cycle which may lead to aneuploidy...
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