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Carcinoma of the prostate is the most commonly diagnosed malignancy among North American males. Currently it is the most commonly diagnosed cancer in men and is the second leading cause of cancer mortality following lung cancer (1–3). Recently, increases in the number of men diagnosed with prostate cancer has been attributed to an increase in the awareness of the disease as well as to better improvements...
Background and PurposeDNA hypomethylation was previously implicated in metastasis. In the present study, we examined whether methyl supplementation with the universal methyl donor S‐adenosylmethionine (SAM) inhibits prostate cancer associated skeletal metastasis.
Experimental ApproachHighly invasive human prostate cancer cells PC‐3 and DU‐145 were treated with vehicle alone, S‐adenosylhomocysteine...
Heterochromatin serves important functions, protecting genome integrity and stabilizing gene expression programs. Although the Suv39h methyltransferases (KMTs) are known to ensure pericentric H3K9me3 methylation, the mechanisms that initiate and maintain mammalian heterochromatin organization remain elusive. We developed a biochemical assay and used in vivo analyses in mouse embryonic fibroblasts...
Epigenetic modifications are thought to be important for gene expression changes during development and aging. However, besides the Sir2 histone deacetylase in somatic tissues and H3K4 trimethylation in germlines, there is scant evidence implicating epigenetic regulations in aging. The insulin/IGF-1 signaling (IIS) pathway is a major life span regulatory pathway. Here, we show that progressive increases...
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