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Latino youth in urban centers, and more specifically those in families dealing with the challenges of recent immigration to the United States, have special sources of risk for substance abuse and related problems. Project HOPE focused on such a group: Latino seventh and eighth graders in English as a Second Language (ESL) classes at middle school sites with particularly high concentrations of Latino youth. The overriding goals of the project were: (a) to increase protective factors at the individual, family and school level that are likely to lead to reduced abuse of alcohol and other drugs; and (2) to produce actual reductions in rates of use of alcohol, cigarettes, and marijuana. This report describes the results from the third year of this project....