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The square-planar bis chelate complexes Ni(R-sal) 2 (= bis(N-alkyl)salicylaldiminato)nickel(II)) with R = (CH 2 ) 2 Ph (I; Ph = phenyl), (CH 2 ) 3 Ph (II), (CH 2 ) 4 Ph (III) and (CH 2 ) 2 (4-hydroxyphenyl) (IV) were prepared and characterized. Complexes II and III meet the steric requirements for intramolecular aromatic...
Summary With the exception of ob/ob mice, circulating plasma leptin is elevated in all other obese rodents as well as in obese humans, suggesting that leptin resistance rather than leptin deficiency is a characteristic feature of obesity. The exact molecular mechanisms leading to leptin resistance and the applicability of exogenous leptin to overcome resistance to the anorectic effect of the hormone,...
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