Search results for: Christian L. Roth

Items from 1 to 20 out of 32 results

article

Acquired hypothalamic obesity: A clinical overview and update

Christian L. Roth, Shana E. McCormack

Diabetes, Obesity and Metabolism > 26 > S2 > 34 - 45

Hypothalamic obesity (HO) is a rare and complex disorder that confers substantial morbidity and excess mortality. HO is a unique subtype of obesity characterized by impairment in the key brain pathways that regulate energy intake and expenditure, autonomic nervous system function, and peripheral hormonal signalling. HO often occurs in the context of hypothalamic syndrome, a constellation of symptoms...

article

MRI measures of hypothalamic injury are associated with glucagon‐like peptide‐1 receptor agonist treatment response in people with hypothalamic obesity

Francisco A. Perez, Clinton Elfers, Jack A. Yanovski, Ashley H. Shoemaker, more

Diabetes, Obesity and Metabolism > 23 > 7 > 1532 - 1541

Aim To evaluate whether neuroimaging‐delineated regions of hypothalamic injury are associated with a differential treatment response to a glucagon‐like peptide‐1 receptor agonist (GLP‐1RA) in patients with hypothalamic obesity (HO). Materials and Methods We performed a prespecified secondary analysis of a randomized, multicentre, double‐blind, placebo‐controlled trial of people aged 10–25 years...

article

Pilot multi‐site and reproducibility study of hypothalamic gliosis in children

Leticia E. Sewaybricker, Susan J. Melhorn, Afroditi Papantoni, Mary F. Webb, more

Pediatric Obesity > 16 > 4 > n/a - n/a

Objective Quantitative magnetic resonance imaging (MRI) evidence of mediobasal hypothalamic (MBH) gliosis positively correlates with body mass index (BMI) in adults. This has neither been well explored in children nor have other brain regions involved in appetitive processing been tested for evidence of gliosis. Methods Multi‐site cross‐sectional study in children to test for differences in quantitative...

article

A phase 3 randomized clinical trial using a once‐weekly glucagon‐like peptide‐1 receptor agonist in adolescents and young adults with hypothalamic obesity

Christian L. Roth, Francisco A. Perez, Kathryn B. Whitlock, Clinton Elfers, more

Diabetes, Obesity and Metabolism > 23 > 2 > 363 - 373

Aim To evaluate the efficacy, safety and tolerability of a glucagon‐like peptide‐1 receptor agonist (GLP‐1 RA) in patients with hypothalamic obesity (HO). Materials and Methods A two‐arm, randomized, multicentre, double‐blind, placebo‐controlled trial was conducted in 10‐ to 25‐year‐olds with hypothalamic injury following intracranial tumour and HO. Participants were randomized to once‐weekly subcutaneous...

article

Cover Image, Volume 20, Issue 5

Elizabeth G. Mietlicki‐Baase, Claudia G. Liberini, Jayme L. Workinger, Ron L. Bonaccorso, more

Diabetes, Obesity and Metabolism > 20 > 5 > i - i

The cover image, by Elizabeth G. Mietlicki‐Baase et al., is based on the Original Article A vitamin B12 conjugate of exendin‐4 improves glucose tolerance without associated nausea or hypophagia in rodents, DOI: 10.1111/dom.13222.

article

A vitamin B12 conjugate of exendin‐4 improves glucose tolerance without associated nausea or hypophagia in rodents

Elizabeth G. Mietlicki‐Baase, Claudia G. Liberini, Jayme L. Workinger, Ron L. Bonaccorso, more

Diabetes, Obesity and Metabolism > 20 > 5 > 1223 - 1234

Aims While pharmacological glucagon‐like peptide‐1 receptor (GLP‐1R) agonists are FDA‐approved for treating type 2 diabetes mellitus (T2DM) and obesity, a major side effect is nausea/malaise. We recently developed a conjugate of vitamin B12 (B12) bound to the GLP‐1R agonist exendin‐4 (Ex4), which displays enhanced proteolytic stability and retention of GLP‐1R agonism. Here, we evaluate whether the...

article

Rising Obesity in Children: A Serious Public Health Concern

Christian L. Roth, Vandana Jain

The Indian Journal of Pediatrics > 2018 > 85 > 6 > 461-462

article

Probiotic strains and mechanistic insights for the treatment of type 2 diabetes

Christiane S. Hampe, Christian L. Roth

Endocrine > 2017 > 58 > 2 > 207-227

Introduction The intestinal microbial composition appears to differ between healthy controls and individuals with Type 2 diabetes (T2D). This observation has led to the hypothesis that perturbations of the intestinal microbiota may contribute to the development of T2D. Manipulations of the intestinal microbiota may therefore provide a novel approach in the prevention and treatment of T2D. Indeed,...

article

Betatrophin: no relation to glucose metabolism or weight status in obese children before and after lifestyle intervention

Christian L. Roth, Clinton Elfers, Nina Lass, Thomas Reinehr

Pediatric Diabetes > 18 > 6 > 485 - 491

Objective The influences of obesity, glucose metabolism, gender, and puberty on betatrophin levels and the longitudinal relationships between weight loss, metabolic changes and betatrophin have not yet been studied in childhood. Methods Cross‐sectional and longitudinal analysis of weight status (standard deviation score‐body mass index (SDS‐BMI)), homeostasis model assessment insulin resistance...

article

α-Melanocyte stimulating hormone promotes muscle glucose uptake via melanocortin 5 receptors

Pablo J. Enriori, Weiyi Chen, Maria C. Garcia-Rudaz, Bernadette E. Grayson, more

Molecular Metabolism > 2016 > 5 > 10 > 807-822

Central melanocortin pathways are well-established regulators of energy balance. However, scant data exist about the role of systemic melanocortin peptides. We set out to determine if peripheral α-melanocyte stimulating hormone (α-MSH) plays a role in glucose homeostasis and tested the hypothesis that the pituitary is able to sense a physiological increase in circulating glucose and responds by secreting...

chapter

Zentrale Regulation des Körpergewichtes

Christian L. Roth

Pädiatrische Endokrinologie und Diabetologie > Energiebilanz > 215-227

In den letzten drei Jahrzehnten konnte man eine dramatische Zunahme der Adipositasrate beobachten. Die Betrachtung von Energiebilanz und Regulation des Körpergewichtes rückt daher zunehmend in den Fokus eines pädiatrischen Endokrinologen. Das Körpergewicht wird durch zahlreiche äußere und innere Einflussfaktoren sowie periphere und zentrale, meist redundante Regelmechanismen bestimmt. Neben dem individuellen...

chapter

Störungen der Geschlechtsentwicklung und der Pubertät

Olaf Hiort, Christian L. Roth, Heike Jung

Klinische Endokrinologie für Frauenärzte > Die gestörten Funktionen > 305-334

Gelegentlich hat sich der Frauenarzt mit klinischen Fragestellungen zu befassen, die in die Phase der Kindheit, der Pubertät und der Adoleszenz fallen. Diese betreffen: Angeborene Störungen der Geschlechtsentwicklung und -reifung Erworbene körperliche Fehlentwicklungen in Kindheit und Pubertät Zyklusstörungen und Androgenisierungserscheinungen in diesen Entwicklungsphasen...

article

Semiquantitative analysis of hypothalamic damage on MRI predicts risk for hypothalamic obesity

Christian L. Roth, Hedieh Eslamy, David Werny, Clinton Elfers, more

Obesity > 23 > 6 > 1226 - 1233

ObjectiveExcessive weight gain frequently occurs in patients with hypothalamic tumors and lesions leading to hypothalamic obesity (HO). MethodsDigital brain magnetic resonance imaging (MRI) and clinical outcomes were studied retrospectively in a single center, including 45 children with postoperative lesions in the sellar region (41 craniopharyngiomas, 4 with Rathke's cleft cysts), ∼5 years post‐surgery,...

article

The gut sensor as regulator of body weight

Thomas Reinehr, Christian L. Roth

Endocrine > 2015 > 49 > 1 > 35-50

The gastrointestinal (GI) tract comprises a large endocrine organ that regulates not only nutrient sensing and metabolising but also satiety and energy homeostasis. More than 20 hormones secreted from the stomach, intestine, and pancreas as well as signaling mediators of the gut microbiome are involved in this process. A better understanding of how related pathways affect body weight and food intake...

article

Initial evidence that GLP-1 receptor blockade fails to suppress postprandial satiety or promote food intake in humans

Susan J. Melhorn, Vidhi Tyagi, Anne Smeraglio, Christian L. Roth, more

Appetite > 2014 > 82 > Complete > 85-90

Glucagon-like peptide 1 (GLP-1) has incretin effects that are well-documented, but the independent role of GLP-1 action in human satiety perception is debated. We hypothesized that blockade of GLP-1 receptors would suppress postprandial satiety and increase voluntary food intake. After an overnight fast, eight normal weight participants (seven men, BMI 19–24.7 kg/m ² , age 19–29 year) were...

article

Reduced adiponectin signaling due to weight gain results in nonalcoholic steatohepatitis through impaired mitochondrial biogenesis

Priya Handa, Bryan D. Maliken, James E. Nelson, Vicki Morgan‐Stevenson, more

Hepatology > 60 > 1 > 133 - 145

Obesity and adiponectin depletion have been associated with the occurrence of nonalcoholic fatty liver disease (NAFLD). The goal of this study was to identify the relationship between weight gain, adiponectin signaling, and development of nonalcoholic steatohepatitis (NASH) in an obese, diabetic mouse model. Leptin‐receptor deficient (Lepr^db/db) and C57BL/6 mice were administered a diet high in unsaturated...

article

Glucocorticoids and insulin resistance in children with acute lymphoblastic leukemia

Eric J. Chow, Catherine Pihoker, Debra L. Friedman, Stephanie J. Lee, more

Pediatric Blood & Cancer > 60 > 4 > 621 - 626

BackgroundChildren treated for acute lymphoblastic leukemia (ALL) are more likely to become overweight. Prolonged exposure to high‐dose glucocorticoids may cause insulin resistance and facilitate development of this phenotype. ProcedureBody mass indices (BMI) and insulin resistance (homeostatic model assessment [HOMA]‐IR) were prospectively measured among on‐ (n = 31) and off‐therapy participants...

article

Brain-derived neurotrophic factor and its relation to leptin in obese children before and after weight loss

Christian L. Roth, Clinton Elfers, Ursel Gebhardt, Hermann L. Müller, more

Metabolism > 2013 > 62 > 2 > 226-234

Brain-derived neurotrophic factor (BDNF) is a regulator of energy homeostasis and food intake through hypothalamic signaling. Currently, data regarding BDNF in children with obesity are lacking. We evaluated serum BDNF concentrations in obese children, both before and after lifestyle intervention, in reference to those of lean children.A total of 90 (24 normal weight; 66 obese) children were studied...

article

Vitamin D deficiency in obese rats exacerbates nonalcoholic fatty liver disease and increases hepatic resistin and toll‐like receptor activation

Christian L. Roth, Clinton T. Elfers, Dianne P. Figlewicz, Susan J. Melhorn, more

Hepatology > 55 > 4 > 1103 - 1111

Childhood obesity is associated with type 2 diabetes mellitus and nonalcoholic fatty liver disease (NAFLD). Recent studies have found associations between vitamin D deficiency (VDD), insulin resistance (IR), and NAFLD among overweight children. To further explore mechanisms mediating these effects, we fed young (age 25 days) Sprague‐Dawley rats with a low‐fat diet (LFD) alone or with vitamin D depletion...

article

Mechanisms affecting neuroendocrine and epigenetic regulation of body weight and onset of puberty: Potential implications in the child born small for gestational age (SGA)

Christian L. Roth, Sheela Sathyanarayana

Reviews in Endocrine and Metabolic Disorders > 2012 > 13 > 2 > 129-140

Signaling peptides produced in peripheral tissues such as gut, adipose tissue, and pancreas communicate with brain centers, such as hypothalamus and hindbrain to manage energy homeostasis. These regulatory mechanisms of energy intake and storage have evolved during long periods of hunger in the evolution of man to protect the species from extinction. It is now clear that these circuitries are influenced...

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INFONA - science communication portal

Search results for: Christian L. Roth

Acquired hypothalamic obesity: A clinical overview and update

MRI measures of hypothalamic injury are associated with glucagon‐like peptide‐1 receptor agonist treatment response in people with hypothalamic obesity

Pilot multi‐site and reproducibility study of hypothalamic gliosis in children

A phase 3 randomized clinical trial using a once‐weekly glucagon‐like peptide‐1 receptor agonist in adolescents and young adults with hypothalamic obesity

Cover Image, Volume 20, Issue 5

A vitamin B12 conjugate of exendin‐4 improves glucose tolerance without associated nausea or hypophagia in rodents

Rising Obesity in Children: A Serious Public Health Concern

Probiotic strains and mechanistic insights for the treatment of type 2 diabetes

Betatrophin: no relation to glucose metabolism or weight status in obese children before and after lifestyle intervention

α-Melanocyte stimulating hormone promotes muscle glucose uptake via melanocortin 5 receptors

Zentrale Regulation des Körpergewichtes

Störungen der Geschlechtsentwicklung und der Pubertät

Semiquantitative analysis of hypothalamic damage on MRI predicts risk for hypothalamic obesity

The gut sensor as regulator of body weight

Initial evidence that GLP-1 receptor blockade fails to suppress postprandial satiety or promote food intake in humans

Reduced adiponectin signaling due to weight gain results in nonalcoholic steatohepatitis through impaired mitochondrial biogenesis

Glucocorticoids and insulin resistance in children with acute lymphoblastic leukemia

Brain-derived neurotrophic factor and its relation to leptin in obese children before and after weight loss

Vitamin D deficiency in obese rats exacerbates nonalcoholic fatty liver disease and increases hepatic resistin and toll‐like receptor activation

Mechanisms affecting neuroendocrine and epigenetic regulation of body weight and onset of puberty: Potential implications in the child born small for gestational age (SGA)

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