Search results for: Chen Chen

Items from 1 to 20 out of 3,824 results

article

Experimental study of the synergistic effect and network regulation mechanisms of an applied combination of BMP‐2, VEGF, and TGF‐β1 on osteogenic differentiation

Zhihao Wang, Jian Sun, Yali Li, Chen Chen, more

Journal of Cellular Biochemistry > 121 > 3 > 2394 - 2405

The study aimed to explore the osteogenic effect induced by the combined use of bone morphogenetic protein‐2 (BMP‐2), vascular endothelial growth factor (VEGF), and transforming growth factor‐β1 (TGF‐β1), attain the best combination for osteogenic quality and efficiency, and explore the network regulation mechanisms of induced osteogenesis. MC3T3‐E1 cells were cultured in vitro, and BMP‐2, VEGF, and...

article

Effects of plant diversity on soil carbon in diverse ecosystems: a global meta‐analysis

Xinli Chen, Han Y. H. Chen, Chen Chen, Zilong Ma, more

Biological Reviews > 95 > 1 > 167 - 183

Soil organic carbon (SOC) is a valuable resource for mediating global climate change and securing food production. Despite an alarming rate of global plant diversity loss, uncertainties concerning the effects of plant diversity on SOC remain, because plant diversity not only stimulates litter inputs via increased productivity, thus enhancing SOC, but also stimulates microbial respiration, thus reducing...

article

Functional diversity enhances, but exploitative traits reduce tree mixture effects on microbial biomass

Chen Chen, Han Y. H. Chen, Xinli Chen, Julia Koricheva

Functional Ecology > 34 > 1 > 276 - 286

Soil micro‐organisms play key roles in terrestrial biodiversity and ecosystem functions. Despite recent progress in elucidating the association between plant diversity and soil micro‐organisms, it remains unclear whether the functional properties of plant mixtures might alter this association. We examined whether the effects of tree species mixtures on soil microbial biomass were impacted by the...

article

Developing a hands‐on activity using virtual reality to help students learn by doing

Jyun‐Chen Chen, Yun Huang, Kuen‐Yi Lin, Yu‐Shan Chang, more

Journal of Computer Assisted Learning > 36 > 1 > 46 - 60

This study combined virtual reality (VR) technology, the 6E (Engage, Explore, Explain, Engineer, Enrich, and Evaluate) model, and STEM (Science, Technology, Engineering, and Mathematics) education to develop a hands‐on activity aimed at helping students to achieve “learning by doing.” The participants were 162 tenth‐grade students, divided into the Experimental Group (hands‐on activity using VR technology)...

article

The relationship of workplace violence and nurse outcomes: Gender difference study on a propensity score matched sample

Mengqi Li, Jiali Liu, Jing Zheng, Ke Liu, more

Journal of Advanced Nursing > 76 > 2 > 600 - 610

Aims To investigate workplace violence and nurse outcomes by comparing gender differences. Design A secondary analysis of cross‐sectional survey data. Methods Workplace violence was measured by four items from the International Hospital Outcome Study. Nurse outcomes were measured by tools including burnout, job satisfaction and intention to stay. We used propensity score matching to generate...

article

Efficient Semi‐Synthesis of Atypical Ubiquitin Chains and Ubiquitin‐Based Probes Forged by Thioether Isopeptide Bonds

Guo‐Chao Chu, Xiao Hua, Chong Zuo, Chen‐Chen Chen, more

Chemistry – A European Journal > 25 > 72 > 16668 - 16675

The development of powerful and general methods to acquire ubiquitin (Ub) chains has prompted the deciphering of Ub‐mediated processes. Herein, the cysteine‐aminoethylation assisted chemical ubiquitination (CAACU) strategy is extended and improved to enable the efficient semi‐synthesis of atypical Ub chain analogues and Ub‐based probes. Combining the Cys aminoethylation and the auxiliary‐mediated...

article

Resveratrol Attenuates Pressure Overload‐Induced Cardiac Fibrosis and Diastolic Dysfunction via PTEN/AKT/Smad2/3 and NF‐κB Signaling Pathways

Lei‐Xin Zou, Chen Chen, Xiao Yan, Qiu‐Yue Lin, more

Molecular Nutrition & Food Research > 63 > 24 > n/a - n/a

Scope Cardiac fibrosis is a key feature of cardiac remodeling. Recently, a protective role for resveratrol (RES) in pressure‐overload‐induced cardiac hypertrophy and contractile dysfunction has been demonstrated. However, the effect of RES on cardiac fibrosis and diastolic function in this model remains unclear. Methods and results Cardiac remodeling is induced in mice by transverse aortic constriction...

article

Brugada syndrome with SCN5A mutations exhibits more pronounced electrophysiological defects and more severe prognosis: A meta‐analysis

Chen Chen, Zhaochong Tan, Wengen Zhu, Linghua Fu, more

Clinical Genetics > 97 > 1 > 198 - 208

Whether the presence of SCN5A mutation is a predictor of BrS risk remains controversial, and patient selection bias may have weakened previous findings. Therefore, we performed this study to clarify the clinical characteristics and outcomes of BrS probands with SCN5A mutations. We systematically retrieved eligible studies published through October 2018. A total of 17 studies enrolling 1780 BrS patients...

article

Advance of sporadic Alzheimer's disease animal models

Lili Zhang, Chen Chen, Marvin SH Mak, Junfeng Lu, more

Medicinal Research Reviews > 40 > 1 > 431 - 458

Alzheimer's disease (AD), the most common form of dementia, is a progressive neurodegenerative disease. In the past decades, numbers of promising drug candidates showed significant anti‐AD effects in preclinical studies but failed in clinical trials. One of the major reasons might be the limitation of appropriate animal models for evaluating anti‐AD drugs. More than 95% of AD cases are sporadic AD...

article

The effect of first high school science teacher's gender and gender matching on students' science identity in college

Chen Chen, Gerhard Sonnert, Philip M. Sadler

Science Education > 104 > 1 > 75 - 99

To encourage the formation of science identity among girls, many scholars and practitioners have suggested to assign same‐gender science teachers to students so that the teachers can serve as gender role models. However, direct evidence of any long‐term effect of gender‐matching is scarce. In a nationally representative survey of college students from the United States, we investigated if gender‐matching...

article

Closing the Gap: Fostering Successful Research‐Practice Partnerships in Counselor Education

Danica G. Hays, Todd Bolin, Ching‐Chen Chen

Counselor Education and Supervision > 58 > 4 > 278 - 292

Research‐practice partnerships offer counselor educators an opportunity to generate scholarship that can promote client welfare and create systemic change in practice and policy. The purpose of this article is to articulate strategies for building and sustaining research‐practice partnerships, as well as suggest methods for evaluating these partnerships.

article

The role of Toll-like receptor 4 in apoptosis of brain tissue after induction of intracerebral hemorrhage

Xiaowei Fei, Yeting He, Jia Chen, Weitao Man, more

Journal of Neuroinflammation > 2019 > 16 > 1 > 1-14

Background Inflammation and apoptosis caused by intracerebral hemorrhage (ICH) are two important factors that affect patient prognosis and survival. Toll-like receptor 4 (TLR4) triggers activation of the inflammatory pathway, causing synthesis and release of inflammatory factors. The inflammatory environment also causes neuronal apoptosis. However, no studies have reported the role of TLR4 in inflammation...

article

The interplay between m6A RNA methylation and noncoding RNA in cancer

Shuai Ma, Chen Chen, Xiang Ji, Jinbo Liu, more

Journal of Hematology & Oncology > 2019 > 12 > 1 > 1-15

N6-methyladenosine (m6A) methylation, one of the most common RNA modifications, has been reported to execute important functions that affect normal life activities and diseases. Most studies have suggested that m6A modification can affect the complexity of cancer progression by regulating biological functions related to cancer. M6A modification of noncoding RNAs regulates the cleavage, transport,...

article

Hepatitis B virus reactivation in cancer patients with positive Hepatitis B surface antigen undergoing PD-1 inhibition

Xuanye Zhang, Yixin Zhou, Chen Chen, Wenfeng Fang, more

Journal for ImmunoTherapy of Cancer > 2019 > 7 > 1 > 1-10

Background Hepatitis B virus (HBV) reactivation is a serious complication in patients with cancers and HBV infection undergoing immunosuppressant treatment or chemotherapy. However, the safety of anti-programmed cell death (PD) -1 and anti-programmed cell death-ligand 1 (PD-L1) therapy in these patients is unknown because they were excluded from clinical trials of immunotherapy. Methods This retrospective...

article

LncRNA-HGBC stabilized by HuR promotes gallbladder cancer progression by regulating miR-502-3p/SET/AKT axis

Yun-ping Hu, Yun-peng Jin, Xiang-song Wu, Yang Yang, more

Molecular Cancer > 2019 > 18 > 1 > 1-18

Backgrounds Long non-coding RNAs (lncRNAs) are essential factors that regulate tumor development and metastasis via diverse molecular mechanisms in a broad type of cancers. However, the pathological roles of lncRNAs in gallbladder carcinoma (GBC) remain largely unknown. Here we discovered a novel lncRNA termed lncRNA Highly expressed in GBC (lncRNA-HGBC) which was upregulated in GBC tissue and aimed...

article

Dietary mulberry leaf powder affects growth performance, carcass traits and meat quality in finishing pigs

Yingying Liu, Yinghui Li, Yinglin Peng, Jianhua He, more

Journal of Animal Physiology and Animal Nutrition > 103 > 6 > 1934 - 1945

This study was conducted to evaluate the effect of mulberry leaves as an alternative source of protein on growth performance, carcass traits and meat quality in finishing pigs. A total of 180 Xiangcun Black pigs were randomly assigned to five treatment groups with six pens of six pigs per pen. The pigs were provided with a basal diet or a diet contained 3%, 6%, 9% or 12% of mulberry leaf powder during...

article

Combined associations of hs-CRP and cognitive function with all-cause mortality among oldest-old adults in Chinese longevity areas: a prospective cohort study

Chen Chen, Yingchun Liu, Zhaojin Cao, Zhaoxue Yin, more

Immunity & Ageing > 2019 > 16 > 1 > 1-9

Background Inflammatory markers, such as high sensitivity C-reactive protein (hs-CRP), and cognitive impairment (CI) are associated with mortality; CRP is related to the deterioration of CI. However, it is still unknown whether these two indices predict mortality independent of each other. Furthermore, their joint effect on all-cause mortality has not been well established, especially in oldest-old...

article

Correlation between kidney transplantation and colorectal cancer in hemodialysis patients: A nationwide, retrospective, population-based cohort study

Han-En Wang, Yu-Chan Liao, Je-Ming Hu, Wen-Chih Wu, more

BMC Cancer > 2019 > 19 > 1 > 1-7

Background Kidney transplantation (KT) correlates with an increased risk of developing several malignancies; however, the risk of colorectal cancer (CRC) after KT remains debatable and has been marginally explored. Hence, in this nationwide, retrospective, population-based cohort study, we aimed to examine the correlation between KT and CRC in a large-scale population-based Chinese cohort. Methods...

article

Self‐Generation of Surface Roughness by Low‐Surface‐Energy Alkyl Chains for Highly Stable Superhydrophobic/Superoleophilic MOFs with Multiple Functionalities

Neng‐Xiu Zhu, Zhang‐Wen Wei, Cheng‐Xia Chen, Dawei Wang, more

Angewandte Chemie International Edition > 58 > 47 > 17033 - 17040

We transformed the hydrophilic metal–organic framework (MOF) UiO‐67 into hydrophobic UiO‐67‐Rs (R=alkyl) by introducing alkyl chains into organic linkers, which not only protected hydrophilic Zr₆O₈ clusters to make the MOF interspace superoleophilic, but also led to a rough crystal surface beneficial for superhydrophobicity. The UiO‐67‐Rs displayed high acid, base, and water stability, and long alkyl...

article

Self‐Generation of Surface Roughness by Low‐Surface‐Energy Alkyl Chains for Highly Stable Superhydrophobic/Superoleophilic MOFs with Multiple Functionalities

Neng‐Xiu Zhu, Zhang‐Wen Wei, Cheng‐Xia Chen, Dawei Wang, more

Angewandte Chemie > 131 > 47 > 17189 - 17196

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INFONA - science communication portal

Search results for: Chen Chen

Experimental study of the synergistic effect and network regulation mechanisms of an applied combination of BMP‐2, VEGF, and TGF‐β1 on osteogenic differentiation

Effects of plant diversity on soil carbon in diverse ecosystems: a global meta‐analysis

Functional diversity enhances, but exploitative traits reduce tree mixture effects on microbial biomass

Developing a hands‐on activity using virtual reality to help students learn by doing

The relationship of workplace violence and nurse outcomes: Gender difference study on a propensity score matched sample

Efficient Semi‐Synthesis of Atypical Ubiquitin Chains and Ubiquitin‐Based Probes Forged by Thioether Isopeptide Bonds

Resveratrol Attenuates Pressure Overload‐Induced Cardiac Fibrosis and Diastolic Dysfunction via PTEN/AKT/Smad2/3 and NF‐κB Signaling Pathways

Brugada syndrome with SCN5A mutations exhibits more pronounced electrophysiological defects and more severe prognosis: A meta‐analysis

Advance of sporadic Alzheimer's disease animal models

The effect of first high school science teacher's gender and gender matching on students' science identity in college

Closing the Gap: Fostering Successful Research‐Practice Partnerships in Counselor Education

The role of Toll-like receptor 4 in apoptosis of brain tissue after induction of intracerebral hemorrhage

The interplay between m6A RNA methylation and noncoding RNA in cancer

Hepatitis B virus reactivation in cancer patients with positive Hepatitis B surface antigen undergoing PD-1 inhibition

LncRNA-HGBC stabilized by HuR promotes gallbladder cancer progression by regulating miR-502-3p/SET/AKT axis

Dietary mulberry leaf powder affects growth performance, carcass traits and meat quality in finishing pigs

Combined associations of hs-CRP and cognitive function with all-cause mortality among oldest-old adults in Chinese longevity areas: a prospective cohort study

Correlation between kidney transplantation and colorectal cancer in hemodialysis patients: A nationwide, retrospective, population-based cohort study

Self‐Generation of Surface Roughness by Low‐Surface‐Energy Alkyl Chains for Highly Stable Superhydrophobic/Superoleophilic MOFs with Multiple Functionalities

Self‐Generation of Surface Roughness by Low‐Surface‐Energy Alkyl Chains for Highly Stable Superhydrophobic/Superoleophilic MOFs with Multiple Functionalities

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