Search results for: Chen Chen

Items from 1 to 20 out of 4,224 results

article

Crosslinkable fluorophenoxy‐substituted poly[bis(octafluoropentoxy) phosphazene] biomaterials with improved antimicrobial effect and hemocompatibility

Shelby Alwine, Chen Chen, Lihui Shen, Harry R. Allcock, more

Journal of Biomedical Materials Research Part B: Applied Biomaterials > 111 > 8 > 1533 - 1545

Biomaterial‐associated microbial infection is one of the most frequent and severe complications associated with the use of biomaterials in medical devices. In previous studies, we developed new fluorinated polyphosphazenes, poly[bis(octafluoropentoxy) phosphazene] (OFP) and crosslinkable OFP (X‐OFP), and demonstrated the inhibition of bacterial adhesion and biofilm formation, thereby controlling microbial...

article

A wideband and low‐profile omnidirectional circularly polarized antenna

Chen‐Chen Xu, Zhu Duan

Microwave and Optical Technology Letters > 65 > 8 > 2293 - 2298

This article presents a wideband and low‐profile omnidirectional circularly polarized antenna. It consists of a circular slotted top patch connected with a circular ground plane by four shorting vias and eight extended curved branches. These curved branches are introduced around both the patch and the ground plane with proper angle separation, achieving a 90‐degree phase difference between the vertical...

article

Identification of the novel HLA‐B46:95N* allele in a Chinese blood donor

Yanmin He, Xuan You, Chen Chen, Wei Zhang, more

HLA > 101 > 6 > 679 - 680

HLA‐B*46:95N shows one nucleotide substitution at position 2 when compared with HLA‐B*46:01:01:01.

article

RNA methyltransferase BmMettl3 and BmMettl14 in silkworm (Bombyx mori) and the regulation of silkworm embryonic development

Bing Li, Pei Hu, Zhi‐Hao Huang, Jia‐Yue Yang, more

Archives of Insect Biochemistry and Physiology > 113 > 2 > n/a - n/a

N6‐methyladenosine (m6A) is a ubiquitous reversible epigenetic RNA modification that plays an important role in regulating many biological processes, especially embryonic development. However, regulation of m6A methylation during silkworm embryonic development and diapause remains to be investigated. In this study, we analyzed the phylogeny of subunits of methyltransferases BmMettl3 and BmMettl14,...

article

Principled leveraging of external data in the evaluation of diagnostic devices via the propensity score‐integrated composite likelihood approach

Changhong Song, Heng Li, Wei‐Chen Chen, Nelson Lu, more

Pharmaceutical Statistics > 22 > 3 > 547 - 569

In the area of diagnostics, it is common practice to leverage external data to augment a traditional study of diagnostic accuracy consisting of prospectively enrolled subjects to potentially reduce the time and/or cost needed for the performance evaluation of an investigational diagnostic device. However, the statistical methods currently being used for such leveraging may not clearly separate study...

article

Enlargement of opisthenar microcirculatory area predicts impaired heart function in severe acute coronary syndrome patients

Chen Chen, Bai Lin Zhu, Wei Da Zheng, Zhen Yi Guo, more

Microcirculation > 30 > 4 > n/a - n/a

Background Impaired microcirculation in acute coronary syndrome (ACS) patients manifests inadequate recovery and adverse clinical outcome. Here, we analyzed correlations between peripheral microcirculation and heart function in ACS patients. Methods Opisthenar microvessel area (OMA) were measured with optical coherence tomography angiography (OCTA), cardiac functional indexes (echocardiograph)...

article

Total saponins of panax ginseng via the CX3CL1/CX3CR1 axis attenuates neuroinflammation and exerted antidepressant‐like effects in chronic unpredictable mild stress in rats

Meng Qin, Chen Chen, Ning Wang, Di Yu, more

Phytotherapy Research > 37 > 5 > 1823 - 1838

Total saponins of Panax ginseng (TSPG) have antidepressant effects. However, the underlying antidepressant mechanism of TSPG remains not clear. This study aimed to predict the mechanism of TSPG by bioinformatics analysis and to verify it experimentally. Bioinformatics analysis showed that the antidepressant effects of TSPG may be related to inflammation, and CX3CL1/CX3CR1 may play a key mediating...

article

Dynamic Reconstitution Between Copper Single Atoms and Clusters for Electrocatalytic Urea Synthesis

Xiaoxiao Wei, Yingying Liu, Xiaorong Zhu, Shuowen Bo, more

Advanced Materials > 35 > 18 > n/a - n/a

Electrocatalytic CN coupling between carbon dioxide and nitrate has emerged to meet the comprehensive demands of carbon footprint closing, valorization of waste, and sustainable manufacture of urea. However, the identification of catalytic active sites and the design of efficient electrocatalysts remain a challenge. Herein, the synthesis of urea catalyzed by copper single atoms decorated on a CeO...

article

Progress on the study of Popeye domain‐containing 3 (POPDC3) in malignancies and striated muscle function and homeostasis

Chen‐Chen Sun, Zhe Zhao, Xi‐Yang Peng, Lan Zheng, more

Clinical Genetics > 103 > 6 > 617 - 624

The Popeye domain‐containing protein 3 (POPDC3), a transmembrane protein with a unique cyclic adenosine monophosphate (cAMP) binding site, is widely expressed in mammalian tissues, with the highest levels of expression in skeletal muscle. POPDC3 plays a key role in many physiological and pathological processes and is considered a candidate biomarker and potential therapeutic target of cancer. In addition,...

article

α‐Benzylation of Carbonyl Compounds Enabled by Synergistic Copper/Amine Catalyzed Decarboxylation of Arylacetic Acids

Kangmei Wen, Mengxia Feng, Qiwen Gao, Chen Chen, more

Advanced Synthesis & Catalysis > 365 > 8 > 1140 - 1146

Herein, we report synergistic copper/amine‐catalyzed reactions for directly α‐benzylating carbonyl compounds with arylacetic acids. These reactions represent the first examples of decarboxylative oxidative synergistic transition‐metal/enamine catalysis for α‐functionalizing carbonyl compounds. The process features starting‐material availability, good functional group tolerance, mild reaction conditions,...

article

C‐Bound or O‐Bound Surface: Which One Boosts Electrocatalytic Urea Synthesis?

Yingying Liu, Xiaojin Tu, Xiaoxiao Wei, Dongdong Wang, more

Angewandte Chemie International Edition > 62 > 19 > n/a - n/a

The electrocatalytic C−N coupling from carbon dioxide and nitrate under ambient conditions is kind of sustainable and promising alternative method for urea synthesis. To date, the influence of catalyst surface properties on molecular adsorption configuration and electrocatalytic urea synthesis activity is unclear. In this work, we proposed that the urea synthesis activity is closely linked with the...

article

C‐Bound or O‐Bound Surface: Which One Boosts Electrocatalytic Urea Synthesis?

Yingying Liu, Xiaojin Tu, Xiaoxiao Wei, Dongdong Wang, more

Angewandte Chemie > 135 > 19 > n/a - n/a

article

Development of HPLC–MS/MS assay for quantitation of ensartinib in human plasma and its application to a pharmacokinetics study in Chinese patients

Hua Li, Yang Wang, Xuefei Chen, Chen Chen, more

Biomedical Chromatography > 37 > 5 > n/a - n/a

Ensartinib is a novel anaplastic lymphoma kinase (ALK) inhibitor with potent activity against a broad range of known crizotinib‐resistant ALK mutations and is developed to treat patients with non‐small‐cell lung cancer. This study was the first to develop and validate a rapid and sensitive HPLC–MS/MS method for the determination of ensartinib in human plasma. The plasma samples were extracted using...

article

Long‐term risk of herpes zoster following COVID‐19: A retrospective cohort study of 2 442 686 patients

Yi‐Chen Chen, Chung‐Han Ho, Ting‐Hui Liu, Jheng‐Yan Wu, more

Journal of Medical Virology > 95 > 4 > n/a - n/a

The long‐term risk of herpes zoster (HZ) after recovery from a SARS‐CoV‐2 infection is unclear. This retrospective cohort study assessed the risk of HZ in patients following a COVID‐19 diagnosis. This retrospective, propensity score‐matched cohort study was based on the multi‐institutional research network TriNetX. The risk of incident HZ in patients with COVID‐19 was compared with that of those not...

article

High Durability of Fe–N–C Single‐Atom Catalysts with Carbon Vacancies toward the Oxygen Reduction Reaction in Alkaline Media

Hao Tian, Ailing Song, Peng Zhang, Kaian Sun, more

Advanced Materials > 35 > 14 > n/a - n/a

Single‐atom catalysts (SACs) have attracted extensive interest to catalyze the oxygen reduction reaction (ORR) in fuel cells and metal–air batteries. However, the development of SACs with high selectivity and long‐term stability is a great challenge. In this work, carbon vacancy modified Fe–N–C SACs (Fe_H–N–C) are practically designed and synthesized through microenvironment modulation, achieving high‐efficient...

article

Corrected MRI Pulmonary Transit Time for Identification of Combined Precapillary and Postcapillary Pulmonary Hypertension in Patients With Left Heart Disease

Chao Gong, Xinli Guo, Ke Wan, Chen Chen, more

Journal of Magnetic Resonance Imaging > 57 > 5 > 1518 - 1528

Background The identification of combined precapillary and postcapillary pulmonary hypertension (CpcPH) in patients with pulmonary hypertension (PH) due to left heart disease (LHD) can influence therapy and outcome and is currently based on invasively determined hemodynamic parameters. Purpose To investigate the diagnostic value of MRI‐derived corrected pulmonary transit time (PTTc) in PH‐LHD sub‐grouped...

article

Synthesis of selenophene‐based chalcone analogs and assessment of their biological activity as anticancer agents

Ya‐Chen Chen, Cai‐Wei Li, Jih‐Jung Chen, Tzenge‐Lien Shih

Archiv der Pharmazie > 356 > 4 > n/a - n/a

Selenium is an essential micronutrient that is beneficial to human health. Selenium‐containing drugs have been developed as antioxidants, anti‐inflammatory, and anticancer agents. However, the synthesis of selenium‐containing chalcones has not been fully explored. Therefore, we report the synthesis of novel selenophene‐based chalcone analogs and reveal their biological activities as anticancer agents...

article

Investigation on small volume and long optical path multipass cell using differential evolution algorithm

Mengru Zhang, Chen Chen, Hongda Chen, Weihao Dong, more

Microwave and Optical Technology Letters > 65 > 5 > 1372 - 1378

To solve the contradiction between high performance and portability of tunable diode laser absorption spectroscopy (TDLAS) systems, we propose a multipass cell (MPC) design method based on differential evolution (DE) algorithm, and realize intelligent optimization design of MPC with small volume and long optical path. MPC is the core component of the TDLAS system. The optical path of MPC determines...

article

Mid‐infrared dissolved CO₂ measurement system using the ultra‐compact multipass cell

Hongda Chen, Chen Chen, Weihao Dong, Yongyang Li, more

Microwave and Optical Technology Letters > 65 > 5 > 1319 - 1323

To measure natural gas hydrate, a mid‐infrared dissolved CO₂ measurement system is designed using the tunable diode laser spectroscopy with ultra‐compact multipass cell. The QCL laser of 4319 nm has a scanning range from 2315.05 to 2315.40 cm⁻¹, which contains ¹²CO₂ and ¹³CO₂ for isotope measurement and wide range of concentration detection. The optimized 3f + 1f wavelength modulation method reduces...

article

Species diversity and distribution of the calcareous green macroalgae Halimeda in Taiwan, Spratly Island, and Dongsha Atoll, with the proposal of Halimeda taiwanensis sp. nov.

Sinjai Phetcharat, Kattika Pattarach, Pin‐Chen Chen, Wei‐Lung Wang, more

Phycological Research > 71 > 2 > 116 - 130

The calcified green algal genus Halimeda is one of the most ecologically important but morphologically diverse seaweeds in sub‐tropical and tropical waters. Because of its high morphological plasticity, the identification of Halimeda species based on morphological characters is challenging without the assistance of molecular analysis. To date, the species diversity of Halimeda in Taiwan and its overseas...

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INFONA - science communication portal

Search results for: Chen Chen

Crosslinkable fluorophenoxy‐substituted poly[bis(octafluoropentoxy) phosphazene] biomaterials with improved antimicrobial effect and hemocompatibility

A wideband and low‐profile omnidirectional circularly polarized antenna

Identification of the novel HLA‐B46:95N* allele in a Chinese blood donor

RNA methyltransferase BmMettl3 and BmMettl14 in silkworm (Bombyx mori) and the regulation of silkworm embryonic development

Principled leveraging of external data in the evaluation of diagnostic devices via the propensity score‐integrated composite likelihood approach

Enlargement of opisthenar microcirculatory area predicts impaired heart function in severe acute coronary syndrome patients

Total saponins of panax ginseng via the CX3CL1/CX3CR1 axis attenuates neuroinflammation and exerted antidepressant‐like effects in chronic unpredictable mild stress in rats

Dynamic Reconstitution Between Copper Single Atoms and Clusters for Electrocatalytic Urea Synthesis

Progress on the study of Popeye domain‐containing 3 (POPDC3) in malignancies and striated muscle function and homeostasis

α‐Benzylation of Carbonyl Compounds Enabled by Synergistic Copper/Amine Catalyzed Decarboxylation of Arylacetic Acids

C‐Bound or O‐Bound Surface: Which One Boosts Electrocatalytic Urea Synthesis?

C‐Bound or O‐Bound Surface: Which One Boosts Electrocatalytic Urea Synthesis?

Development of HPLC–MS/MS assay for quantitation of ensartinib in human plasma and its application to a pharmacokinetics study in Chinese patients

Long‐term risk of herpes zoster following COVID‐19: A retrospective cohort study of 2 442 686 patients

High Durability of Fe–N–C Single‐Atom Catalysts with Carbon Vacancies toward the Oxygen Reduction Reaction in Alkaline Media

Corrected MRI Pulmonary Transit Time for Identification of Combined Precapillary and Postcapillary Pulmonary Hypertension in Patients With Left Heart Disease

Synthesis of selenophene‐based chalcone analogs and assessment of their biological activity as anticancer agents

Investigation on small volume and long optical path multipass cell using differential evolution algorithm

Mid‐infrared dissolved CO₂ measurement system using the ultra‐compact multipass cell

Species diversity and distribution of the calcareous green macroalgae Halimeda in Taiwan, Spratly Island, and Dongsha Atoll, with the proposal of Halimeda taiwanensis sp. nov.

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