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H-Scan is a new ultrasound imaging technique that relies on matching a model of pulse-echo formation to the mathematics of a class of Gaussian-weighted Hermite polynomials. This technique may be beneficial in the measurement of relative scatterer sizes and in cancer therapy, particularly for early response to drug treatment. Because current H-scan techniques use focused ultrasound data acquisitions,...
H-scan is a new ultrasound (US) technique that images the relative size of acoustic scatterers. This modality relies on matching a model of pulse-echo formation to the mathematics of a class of Gaussian-weighted Hermite polynomials (GWHP). Parallel convolution filters using the second (GWH2) and eighth (GWH8) components are applied to the radio frequency US data to capture the low and high frequency...
The abnormal vasculature of tumor and the resulting abnormal microenvironment is a major barrier to optimal chemotherapeutic drug delivery. It is well known that ultrasound (US) can increase the permeability of the tumor vessel walls and enhance the accumulation of anticancer drugs. Reconstituted high density lipoproteins (rHDL) nanoparticles (NPs) allow selective delivery of anticancer agents to...
The standard-of-care for evaluating breast tumor response to chemotherapeutic drug treatment remains the assessment of a tumor size change weeks after therapy begins. However, the tumor microenvironment is known to change drastically before any detectable change in physical size manifests. New clinical tools that can help determine early tumor response are urgently needed so we can both maximize the...
The current standard for evaluating breast tumor response to neoadjuvant treatment remains the assessment of a tumor size change several weeks after therapy begins. However, the tumor microenvironment (including microvasculature) is known to change drastically before any detectable change in physical size manifests. To that end, we have developed a new high-resolution ultrasound (US) imaging modality...
In cancer treatment, there is a need to improve chemotherapeutic drug uptake at the local tumor site to both enhance dose efficacy and minimize any toxic side effects. It is well known now that stably cavitating microbubbles (MBs) in an ultrasound (US) field can increase the permeability of tumor blood vessel walls. This consequently can enhance the extravasation and accumulation of a circulating...
H-scan is a new ultrasound (US) technique that images the relative size of acoustic scatterers. This modality relies on matching a model of pulse-echo formation to the mathematics of a class of Gaussian-weighted Hermite polynomials (GH). Parallel convolution filters using the second (GH2) and eighth (GH8) components are applied to the radio frequency (RF) US data to capture the low and high frequency...
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