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Ultrasound-mediated drug delivery using microbubbles is a growing field with applications ranging from targeted chemotherapy to permeating the blood brain barrier. Despite the potential clinical impact of this technique, the precise parameters needed to reliably induce cell sonoporation, or increased cellular permeability, are not well understood. The goal of this work is to use high frame rate imaging...
Ultrasound-mediated drug delivery using microbubbles is a growing field with applications ranging from targeted chemotherapy delivery to permeating the blood brain barrier. However, the precise parameters that induce increased cellular permeability are not fully understood. For sonoporation efficiency, a high microbubble concentration is preferred, but acoustic shadowing limits the ultrasound delivery...
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