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Collecting labeling information of time-to-event analysis is naturally very time consuming, i.e., one has to wait for the occurrence of the event of interest, which may not always be observed for every instance. By taking advantage of censored instances, survival analysis methods internally consider more samples than standard regression methods, which partially alleviates this data insufficiency problem...
Accurately predicting the risk of cancer recurrence and metastasis is critical to cancer individualized treatment. Currently, physicians commonly use histological grade, which is determined by pathologists via performing a semi-quantitative analysis of three histological and cytological features on Hematoxylin-Eosin (HE) stained histopathological images, to assess the prognosis of a breast cancer...
An in vivo flow cytometer and optical imaging are used to assess tumor cell spreading. The depletion rate of circulating tumor cells provides insights in early cancer metastasis. It is useful to understand the molecular mechanisms of tumor metastasis.
A method for the development of patient-specific electromagnetic breast model based on clinical breast MR images is presented. Numerical example of a breast model demonstrates the feasibility of the method. The developed model is not only limited to the use for modeling clinical studies of microwave imaging for breast cancer detection, but also to cancer treatment using hyperthermia.
Brain tumor segmentation is an important image processing step in diagnosis, treatment planning, and follow-up studies of Glioblastoma (GBM). However it is still a challenging task due to varying in size, shape, location, and image intensities within and around the tumor. In this paper, we propose a new brain tumor segmentation method for T1-weighted MR brain images based on an improved level set...
An in vivo flow cytometer and optical imaging are used to assess liver tumor cell spreading. A real- time quantitative monitoring of circulating liver tumor cells by the in vivo flow cytometer will be useful to assess the effectiveness of the potential therapeutic interventions.
Extra-cellular signal regulated kinase (ERK) signal transduction is an important signaling pathway, involved in a variety of processes in cell and closely related to the occurrences of diverse tumors. This raises the question how these diverse functions are specified and coordinated. In this work, we present an integrated computational model of ERK signal transduction pathway, investigating the regulatory...
A recently developed ldquoin vivo flow cytometerrdquo and optical imaging are used to assess leukemic cell spreading and the circulation kinetics, as well as assess the effectiveness of the potential therapeutic interventions.
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