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The activating receptor NKG2D is mainly expressed by human CD8 + T cells and NK cells but normally absent on CD4 + T cells. However, a subset of autoreactive NKG2D + CD4 + T cells has been found to exist in some autoimmune disease such as rheumatoid arthritis (RA) and to participate in the imbalance of immune response and inflammation. Up to date this observation has...
NKG2D receptor–ligand interaction triggers NK cell-mediated cytolysis and IFN-γ secretion. IFN-γ produced by NK cells has been found to promote the interaction between NK cells and monocytes; however, the underlying mechanism remains elusive. We demonstrate here that IFN-γ exclusively induced or upregulated the expression of MHC class I chain-related (MIC) molecules, which are ligands of the NKG2D...
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