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Objective: In vitro models of Mycobacterium tuberculosis (Mtb) nonreplicating persistence (NRP) suggest the rate of oxygen ($O_2$ ) depletion is a significant determinant in persistence. However, few studies have characterized the metabolic association between slow and rapid $O_2$ depletion rates and successful versus failed persistence. Methods: We developed a theoretical model of Mtb metabolic...
This paper describes a method for incorporating a diffusion field modeling oxygen usage and dispersion in a multi-scale model of Mycobacterium tuberculosis (Mtb) infection mediated granuloma formation. We implemented this method over a floating-point field to model oxygen dynamics in host tissue during chronic phase response and Mtb persistence. The method avoids the requirement of satisfying the...
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