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Targeted Protein Deliveries
In article number 2204620, Hak‐Sung Kim and co‐workers develop a new type of protein self‐assembly using human clathrin for a targeted protein delivery. A redesigned clathrin triskelion is dual‐functionalized with functional biomolecules. The resulting clathrin assembly exhibits a significantly high avidity and an efficient delivery of a protein cargo into tumor cells....
Protein assemblies have drawn much attention as platforms for biomedical applications, including gene/drug delivery and vaccine, due to biocompatibility and functional diversity. Here, the construction and functionalization of a protein assembly composed of human clathrin heavy chain and light chain for a targeted protein delivery, is presented. The clathrin heavy and light chains are redesigned and...
Owing to an increase in mobile devices and the advent of the Internet of Things (IoT), mobile traffic has increased exponentially. Consequently, a wide range of research on handover has been conducted to provide mobile device users with stable network quality. Most research on handover uses a network-dependent method that establishes a new protocol or a method that can refine handover time; however,...
In this paper, we studied for the synchronization of CCNx that is one of the Content Centric Network (CCN) projects by using Hazelcast. CCN is considered as a way to solve the explosive growth of Internet traffic. Hazelcast is an open source In-Memory Data Grid. Hazelcast, that one of the consensus-based in-memory data grid, has the strength to speed, high-availability, and secure. To effectively...
Existing NAT solves to IP address exhaustion problem binding private IP address and public IP address, and NAT traversal such as hole punching scheme enables to communicate End-to-End devices located in different private networks. However, such technologies are centralized the workload at NAT gateway and increase transmission delay caused by packet modification per packet. In this paper, we propose...
The use of the proxy server is being extended steadily in order to provide various web services and improve the quality of web service. However, passing many proxy servers may degrade the quality of web service, because of increasing HTTP message processing time. In this paper, we propose a scheme that bypasses many proxy servers constituting proxy chain. Furthermore, we perform network simulation...
Metabolomics technology, employed in the analysis of low-molecular endogenous metabolites (e.g., by NMR, LC/MS, GC/MS) and with statistical algorithms, has been applied to the development of new drugs, the diagnosis of diseases, and a variety of other fields. In the present research, certain endogenous metabolite candidates with which, by application of metabolomics to forensic science, post-mortem...
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