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Aim
Oxidative stress is strongly implicated in many psychiatric disorders, which has resulted in the development of new interventions to attempt to perturb this pathology. A great deal of attention has been paid to glutathione, which is the brain's dominant antioxidant and plays a fundamental role in removing free radicals and other reactive oxygen species. Measurement of glutathione concentration...
A spatially variant resolution modelling technique for PET image reconstruction is presented which models the physical processes of the measurement during the iterative reconstruction. This is achieved by redistributing the line-of-response endpoints according to derived probability density functions describing the detector response function and photon acollinearity. When applying this technique it...
Accurate motion compensated image reconstruction of freely moving small animals requires the exact calculation of the time-weighted sensitivity correction factors. Back-projection of all possible lines of response for every recorded pose is a computationally intensive task, which requires impractically long reconstruction times. In this work we investigated an approach to accelerate this task, by...
The kinetics of single photon emitting macromolecules (e.g. antibodies) are typically slower than small molecules, necessitating long or repeat acquisitions. We previously proposed the use of motion tracking and limited angle tomographic reconstruction to characterise tracer kinetics over extended periods in awake rodents. In this study, we explored this approach by imaging a contrast phantom, moved...
Image reconstruction from Compton camera data is a complex problem requiring investigation. Generally reconstruction is conducted using iterative reconstruction methods such as Maximum Likelihood - Expectation Maximization (MLEM). However, iterative reconstruction into volumetric grids is a computational burden. Analytic methods of image reconstruction have been proposed which relieve the computational...
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