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A biomimetic bearing seal system has been developed to reduce frictional loss and improve the separation of air and water. The seal mimics the material properties and mechanical characteristics of articular cartilage found in natural synovial joints. It is made of the hydrated material polyvinyl formal (PVF), which has a porous structure, high wear resistance, and exhibits low frictional resistance...
An all-new sealing system for a rotating shaft, which specializes in excellent separation between water and air, has been developed for installation in an ocean current or tidal power generator. Two seal lips made of a polyvinyl formal (PVF) were attached to a rotating shaft, and an aqueous solution of 3.0 wt% polyethylene glycol (PEG), a non-Newtonian fluid with a molecular weight of 2.0 million,...
A biomimetic bearing with a fail-safe braking system has been developed for installation in small, lightweight vehicles, or lifts in a production factory. The new design uses a journal bearing configuration where the rotating shaft is supported by an outer bearing lining on a soft material. The soft layer, such as is found in the articular cartilage of natural synovial joint, not only plays a role...
We have synthesized and evaluated a series of tetramic acid-based and hydroxyquinolinone-based inhibitors of plasminogen activator inhibitor-1 (PAI-1). These studies resulted in the identification of several compounds which showed excellent potency against PAI-1. The design, synthesis and SAR of these compounds are described.
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