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In this study, the effects of (a) the minor allele frequency of the single nucleotide variant (SNV), (b) the degree of departure from normality of the trait, and (c) the position of the SNVs on type I error rates were investigated in the Genetic Analysis Workshop (GAW) 19 whole exome sequence data. To test the distribution of the type I error rate, 5 simulated traits were considered: standard normal...
The effects of the minor allele frequency of single nucleotide variants and the degree of departure from normality of a quantitative trait on type I error rates were evaluated using Genetic Analysis Workshop 17 mini-exome sequence data. Four simulated traits were generated: standard normal and gamma distributed traits and two transformations of the gamma distributed trait by log10 and rank-based inverse...
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