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Reliably scoring and ranking candidate models of protein complexes and assigning their oligomeric state from the structure of the crystal lattice represent outstanding challenges. A community‐wide effort was launched to tackle these challenges. The latest resources on protein complexes and interfaces were exploited to derive a benchmark dataset consisting of 1677 homodimer protein crystal structures,...
Rheumatoid arthritis (RA) is associated with abnormal B cell‐functions implicating antibody‐dependent and ‐independent mechanisms. B cells have emerged as important cytokine‐producing cells, and cytokines are well‐known drivers of RA pathogenesis. To identify novel cytokine‐mediated B‐cell functions in RA, we comprehensively analysed the capacity of B cells from RA patients with an inadequate response...
Comparing two sets of multivariate samples is a central problem in data analysis. From a statistical standpoint, the simplest way to perform such a comparison is to resort to a non-parametric two-sample test (TST), which checks whether the two sets can be seen as i.i.d. samples of an identical unknown distribution (the null hypothesis). If the null is rejected, one wishes to identify regions accounting...
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