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Predicting how a protein folds based solely on its amino acid sequence is an ongoing challenge for the fields of Bioinformatics and Computer Science. Previous attempts to solve this problem have relied on algorithms and a specific set of benchmark proteins. However, there is currently no method for determining if the set of benchmark proteins share a similar level of complexity with proteins of similar...
Information transfer is fundamental to all life forms. In the third domain of life, the archaea, many of the genes functioning in these processes are similar to their eukaryotic counterparts, including DNA replication and repair, basal transcription, and translation genes, while many transcriptional regulators and the overall genome structure are more bacterial-like. Among halophilic (salt-loving)...
We examined variants of an especially cold-active β-galactosidase (BgaS) to better understand features affecting enzyme activity at temperature extremes. We targeted locations corresponding to a region in the LacZ enzyme previously shown to increase activity and decrease thermostability. Changes in this region of BgaS consistently caused the elimination or reduction of activity. A gene (bgaS3) encoding...
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