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Synthetic lethality (SL) represents the co‐occurrence of two or more non‐lethal disordered genes that could lead to cell death. SL‐based anticancer therapeutics could specifically kill the cancer cells carrying the targeted mutated gene while leaving normal cells alive. Recent large‐scale computational and experimental screenings provide rich resources of SL information while lacking systematic research...
Monkeypox virus (MPXV) has generally circulated in West and Central Africa since its emergence. Recently, sporadic MPXV infections in several nonendemic countries have attracted widespread attention. Here, we conducted a systematic analysis of the recent outbreak of MPXV‐2022, including its genomic annotation and molecular evolution. The phylogenetic analysis indicated that the MPXV‐2022 strains belong...
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