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This paper presents an optimized MEMS based Silicon Nanotweezers (SNT) for mechanical diagnostic of biological cell. The innovative features of the design are described. The principle of operation are validated by the characterization of model systems and cell deformation experiment.
This paper describes an integrated bio-reaction platform composed of silicon nanotweezers and open microfluidics for real time biomechanical assays. The silicon nanotweezers can sense slight biological modification of the trapped sample due to stable frequency response with high Q factor in liquid. The microfluidic device integrates active valves for controlling the biological medium. Biomolecular...
This paper demonstrates the real-time sensing of enzymatic reactions on a DNA bundle trapped by silicon nanotweezers. The digestion of DNA in protein solution (Hind III) is monitored by tracking the change in frequency response of the immersed tweezers. This new direct biomechanical detection clears the way for systematic bio tests at the molecular level by an integrated MEMS device.
Molecular biophysicists seek to understand how biological systems work through mechanical or electrical characterizations performed at the molecular scale. From this perspective, we have devised a silicon-based micromechanical tool for stress-strain measurements of molecular fibers and demonstrated micro manipulation and biomechanical characterization of DNA bundles in a liquid solution. By combining...
We propose skeletal muscle cells as a new material for Bio-MEMS actuator, and developed the fabrication process to integrate it onto Si-MEMS devices. As the first trial of the integration of the skeletal muscle cells onto the Si-MEMS device, we used a cantilever-based force measurement Si-MEMS device for evaluating the generative force of the muscle cells. Murine skeletal muscle cell line C2C12 myoblasts...
The microorganism, vorticella, of about 50 mum in diameter was found to be capable of mixing beads in microfluidic channel by energizing vortex with its cilia. Vortex generation and flow velocity around the cell body of a vorticella was experimentally studied using both fluorescents and non-fluorescents microbeads of different size (from 0.5 to 20 mum in diameter). Two vortices in two-dimensional...
We describe electrostatically actuated silicon nanotweezers which are intended for the manipulation and characterization of filamentary molecules. The microelectromechanical system consists of a pair of opposing tips whose distance can be accurately adjusted by means of an integrated differential capacitive sensor. The fabrication process is based on silicon-on-insulator technology and combines KOH...
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