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Background With applications in cancer, drug metabolism, and disease etiology, understanding structural variation in the human genome is critical in advancing the thrusts of individualized medicine. However, structural variants (SVs) remain challenging to detect with high sensitivity using short read sequencing technologies. This problem is exacerbated when considering complex SVs comprised of multiple...
The prospect of simpler infrastructure management and affordability has garnered interest in cloud computing from bioinformaticians. However, the performance cost of adopting such an infrastructure model for bioinformatics is not fully known. In an effort to help quantify this performance cost, we ran synthetic benchmarks and measured the runtimes of two short-read alignment applications on cloud-like...
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