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The cytosolic helicase retinoic acid-inducible gene-I (RIG-I) initiates immune responses to most RNA viruses by detecting viral 5′-triphosphorylated RNA (pppRNA). Although endogenous mRNA is also 5′-triphosphorylated, backbone modifications and the 5′-ppp-linked methylguanosine (m7G) cap prevent immunorecognition. Here we show that the methylation status of endogenous capped mRNA at the 5′-terminal...
Network security is dependent upon securing individual components, services, and applications. This is done through the prevention, detection, and correction of threats and attacks that exploit vulnerabilities in the network. Network security must be analyzed using various factors, such as security requirements, the inherent strengths and vulnerabilities of different network technologies, and the...
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