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Obsessive-compulsive disorder (OCD) affects approximately 2% of the general population [1], with remarkably consistent lifetime prevalence in Western countries [2]. The cardinal symptoms of OCD are intrusive thoughts (obsessions) and/or repetitive behaviors (compulsions) that persist against the patient’s attempts to eliminate them. Common themes are checking, washing and cleaning, excessive need...
We have developed a novel type of neural electrode array for future brain-machine interfaces (BMIs) or neural prosthesis requiring high resolution recording and stimulation on the cortex. The microelectrode arrays developed comprise of a down to 5 μm thin stack of platinum and polyimide or Parylene C insulation, which is finely microstructured for increased flexibility. The electrode stack is temporarily...
We have developed a novel type of neural electrode array for future brain-machine interfaces (BMIs) or neural prosthesis requiring high resolution recording and stimulation on the cortex. The microelectrode arrays developed comprise of a thin film stack of platinum and polyimide or Parylene C insulation, which is finely microstructured for increased flexibility. The electrode stack is temporarily...
Contextual conditioning in rats is typically quantified using freezing time or startle amplitude. In this study, we combined both anxiety measures in one procedure and systematically examined the effect of training with 0, 5, 10 or 15 unpaired tone- shock (0.8 mA - 250 ms) presentations on the expression of contextual conditioning in a chronic protocol with two training and testing days. Such a chronic...
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