Search results for: Xiumin Wang

Items from 1 to 20 out of 125 results

article

Integration of Protein Nanocage with CpG Motifs: A Virus‐Mimicked Core‐Shell Nanostructure to Ignite Antitumor Immunity

Qiang Zhang, Junchen Dong, Jiaping Wang, Jiayu Wang, more

Small > 19 > 40 > n/a - n/a

The tumor microenvironment typically possesses immunosuppressive properties that hinder the effectiveness of antitumor immune responses, even in the context of immunotherapies. However, it is observed that pathogenic microorganisms can trigger strong immune responses during infection, offering a potential means to counteract the immunosuppressive environment of tumors. In this study, a protein nanocage...

article

Germline Neurofibromin 1 mutation enhances the anti‐tumour immune response and decreases juvenile myelomonocytic leukaemia tumourigenicity

Wanqiao Wang, Xin Li, Xia Qin, Yan Miao, more

British Journal of Haematology > 202 > 2 > 328 - 343

Juvenile myelomonocytic leukaemia (JMML) is an aggressive paediatric leukaemia characterized by mutations in five canonical RAS pathway genes, including the NF1 gene. JMML is driven by germline NF1 gene mutations, with additional somatic aberrations resulting in the NF1 biallelic inactivation, leading to disease progression. Germline mutations in the NF1 gene alone primarily cause benign neurofibromatosis...

article

Recent progress of bacterial FtsZ inhibitors with a focus on peptides

Huihui Han, Zhenlong Wang, Ting Li, Da Teng, more

The FEBS Journal > 288 > 4 > 1091 - 1106

In recent years, the rise of antibiotic resistance has become a primary health problem. With the emergence of bacterial resistance, the need to explore and develop novel antibacterial drugs has become increasingly urgent. Filamentous temperature‐sensitive mutant Z (FtsZ), a crucial cell division protein of bacteria, has become a vital antibacterial target. FtsZ is a filamentous GTPase; it is highly...

article

Formation Mechanism for the TiN-MnS Complex Inclusions in Tire Cord Steel

Jialiu Lei, Xiumin Wang, Dongnan Zhao, Yongjun Fu

Archives of Foundry Engineering > 2021 > Vol. 21, iss. 2 > 65--69

High strength tire cord steel is extensively used in radial ply tyres as the framework material, but the presence of brittle single titanium inclusions or complex titanium inclusions can cause failure of the wires and jeopardize their performance in production. In order to provide a key guidance on the control of titanium inclusions, it is necessary to clarify their formation mechanism during solidification...

article

Biallelic ERBB3 loss-of-function variants are associated with a novel multisystem syndrome without congenital contracture

Niu Li, Yufei Xu, Yi Zhang, Guoqiang Li, more

Orphanet Journal of Rare Diseases > 2019 > 14 > 1 > 1-10

Background Gain-of-function pathogenic variants of the Erb-B2 receptor tyrosine kinase 3 (ERBB3) gene contribute to the occurrence and development of a variety of human carcinomas through activation of phosphatidylinositol 3-kinase (PI3K)/AKT and extracellular signal-regulated kinase (ERK) signaling. ERBB3 gene homozygous germline variants, whose loss of function may cause autosomal recessive congenital...

article

Molecular and phenotypic spectrum of Noonan syndrome in Chinese patients

Xin Li, Ruen Yao, Xin Tan, Niu Li, more

Clinical Genetics > 96 > 4 > 290 - 299

Noonan syndrome (NS) is a common autosomal dominant/recessive disorder. No large‐scale study has been conducted on NS in China, which is the most populous country in the world. Next‐generation sequencing (NGS) was used to identify pathogenic variants in patients that exhibited NS‐related phenotypes. We assessed the facial features and clinical manifestations of patients with pathogenic or likely pathogenic...

article

An optimized encoding algorithm for systematic polar codes

Xiumin Wang, Zhihong Zhang, Jun Li, Yu Wang, more

EURASIP Journal on Wireless Communications and Networking > 2019 > 2019 > 1 > 1-12

Many different encoding algorithms for systematic polar codes (SPC) have been introduced since SPC was proposed in 2011. However, the number of the computing units of exclusive OR (XOR) has not been optimized yet. According to an iterative property of the generator matrix and particular lower triangular structure of the matrix, we propose an optimized encoding algorithm (OEA) of SPC that can reduce...

article

Biomineralization synthesis of HBc-CuS nanoparticles for near-infrared light-guided photothermal therapy

Qingran Jia, Danyang Li, Qiang Zhang, Shefang Ye, more

Journal of Materials Science > 2019 > 54 > 20 > 13255- 13264

Transition metal sulfide nanoparticles provide efficient tumor photothermal therapy under near-infrared light, while suffering from poor chemical stability and biocompatibility. Protein scaffolds are attractive templates to fabricate various inorganic nanostructures, due to their inherent capabilities of molecular recognition and self-assembly characteristics. Herein, a straightforward method is demonstrated...

article

TRMA syndrome with a severe phenotype, cerebral infarction, and novel compound heterozygous SLC19A2 mutation: a case report

Xin Li, Qing Cheng, Yu Ding, Qun Li, more

BMC Pediatrics > 2019 > 19 > 1 > 1-6

Background Thiamine-responsive megaloblastic anemia (TRMA) is a rare autosomal recessive inherited disease characterized by the clinical triad of megaloblastic anemia, sensorineural deafness, and diabetes mellitus. To date, only 100 cases of TRMA have been reported in the world. Case presentation Here, we describe a six-year-old boy with diabetes mellitus, anemia, and deafness. Additionally, he...

article

A recombinant fungal defensin-like peptide-P2 combats multidrug-resistant Staphylococcus aureus and biofilms

Na Yang, Da Teng, Ruoyu Mao, Ya Hao, more

Applied Microbiology and Biotechnology > 2019 > 103 > 13 > 5193-5213

There is an urgent need to discover new active drugs to combat methicillin-resistant Staphylococcus aureus, which is a serious threat to humans and animals and incompletely eliminated by antibiotics due to its intracellular accumulation in host cells, production of biofilms, and persisters. Fungal defensin-like peptides (DLPs) are emerging as a potential source of new antibacterial drugs due to their...

article

Prolonged high‐glucose exposure decreased SREBP‐1/FASN/ACC in Schwann cells of diabetic mice via blocking PI3K/Akt pathway

Lin Zhu, Wei Du, Yaping Liu, Meijuan Cheng, more

Journal of Cellular Biochemistry > 120 > 4 > 5777 - 5789

Abnormal lipid metabolism and SREBP‐1 downregulation are reported to be involved in the pathogenesis of diabetic peripheral neuropathy (DPN). In the current study, the relationship between PI3K/Akt signaling pathway and SREBP‐1 expression was explored in Schwann cells of DPN. The phospho‐Akt (Ser 473), phospho‐Akt (Thr 308), and SREBP‐1 expression were inhibited in the sciatic nerves of diabetic mice...

article

Clinical and mutation profile of pediatric patients with RASopathy-associated hypertrophic cardiomyopathy: results from a Chinese cohort

Hao Chen, Xin Li, Xiaoliang Liu, Jian Wang, more

Orphanet Journal of Rare Diseases > 2019 > 14 > 1 > 1-8

Background The RASopathies are a class of developmental disorders caused by germline mutations in the RAS-mitogen-activated protein kinase (MAPK) pathway. Hypertrophic cardiomyopathy (HCM) has been frequently described in children with RASopathy, but only a minority of patients have received formal genotyping. The purpose of this study was to evaluate the genetic basis and clinical outcome of pediatric...

article

Optimized sleep strategy based on clustering in dense heterogeneous networks

Jun Li, Hao Wang, Xiumin Wang, Zhengquan Li

EURASIP Journal on Wireless Communications and Networking > 2018 > 2018 > 1 > 1-10

As a large number of small base stations have been deployed in dense heterogeneous networks, the increasing cost of energy has become a challenging issue. In this paper, we propose an optimized clustering-based sleep strategy to release the power consumption and interference in the system. First, we group the small base stations with large interference as a cluster in which the binary particle swarm...

article

Description of the molecular and phenotypic spectrum of Wiedemann-Steiner syndrome in Chinese patients

Niu Li, Yirou Wang, Yu Yang, Pengpeng Wang, more

Orphanet Journal of Rare Diseases > 2018 > 13 > 1 > 1-13

Background Wiedemann–Steiner syndrome (WDSTS) is a rare genetic disorder characterized by facial gestalt, neurodevelopmental delay, skeletal anomalies and growth retardation, which is caused by variation of KMT2A gene. To date, only 2 Chinese WDSTS patients have been reported. Here, we report the phenotypes and KMT2A gene variations in 14 unrelated Chinese WDSTS patients and investigate the phenotypic...

article

On the optimal flow allocation and information theoretically secure network coding design for multiple multicasts

Weiwei Ding, Jin Wang, Xiumin Wang, Kejie Lu, more

International Journal of Communication Systems > 31 > 6 > n/a - n/a

With linear network coding (LNC), the data packets transmitted in a communication network are coded packets, which are linear combinations of original data packets. Since the coded packets can be useful for multiple destinations in multicast, LNC has been shown as a promising technology to improve the network throughput. On the other hand, the original data packets can be encoded with random symbols...

article

A review of the design and modification of lactoferricins and their derivatives

Ya Hao, Na Yang, Da Teng, Xiumin Wang, more

BioMetals > 2018 > 31 > 3 > 331-341

Lactoferricin (Lfcin), a multifunction short peptide with a length of 25 residues, is derived from the whey protein lactoferrin by acidic pepsin hydrolysis. It has potent nutritional enhancement, antimicrobial, anticancer, antiviral, antiparasitic, and anti-inflammatory activities. This review describes the research advantages of the above biological functions, with attention to the molecular design...

article

Molecular dynamics simulations of aggregation behavior of sodium dodecyl sulfate on SiO₂ and CaCO₃ surfaces

Xiumin Wang, Gang Wu, Congtai Yuan, Qianqian Zhu, more

Surface and Interface Analysis > 50 > 3 > 284 - 289

Molecular dynamics simulations were carried out to investigate the aggregation behavior of anionic surfactant sodium dodecyl sulfate (SDS) on the surfaces of SiO₂ and CaCO₃. The results indicate that SDS molecules formed a spherical micelle structure near the SiO₂ surface; moreover, there were more head groups near the SiO₂ surface. However, they could form a self‐assemble film on the CaCO₃ surface...

article

Device-to-Device assisted wireless video delivery with network coding

Cheng Zhan, Zhe Wen, Xiumin Wang, Liyue Zhu

Ad Hoc Networks > 2018 > 69 > C > 76-85

Broadcasting popular data content such as videos to multiple users is widely used in mobile wireless networks. We consider a group of mobile users, within proximity of each other, who are interested in the same video or cloud services. In this scenario, users are able to use device-to-device (D2D) connections, e.g., WiFi or Bluetooth, to get the video in a cooperative way. In this paper we consider...

article

Identification and analysis of the genetic causes in nine unrelated probands with syndromic craniosynostosis

Yufei Xu, Shouqing Sun, Niu Li, Tingting Yu, more

Gene > 2018 > 641 > C > 144-150

Syndromic craniosynostosis is a group of multiple conditions with high heterogeneity, and many rare syndromes still remain to be characterized. To identify and analyze causative genetic variants in nine unrelated probands mainly manifested as syndromic craniosynostosis, we reviewed the relevant medical information of the patients and performed the whole exome sequencing, further verified with Sanger...

article

Load Balanced Mobile User Recruitment for Mobile Crowdsensing Systems

Xin An, Hao Guo, Xiumin Wang, Xiaoming Chen

IEEE Communications Letters > 2017 > 21 > 11 > 2420 - 2423

In this letter, we study the mobile user recruitment problem for mobile crowdsensing systems. Instead of minimizing the overall sensing cost or user utility, this letter aims to optimize the load balancing of the mobile users, which is particularly important for the resource-constrained individual user. We refer to such a problem as the load balanced mobile user recruitment (LB-MUR) problem. Specifically,...

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INFONA - science communication portal

Search results for: Xiumin Wang

Integration of Protein Nanocage with CpG Motifs: A Virus‐Mimicked Core‐Shell Nanostructure to Ignite Antitumor Immunity

Germline Neurofibromin 1 mutation enhances the anti‐tumour immune response and decreases juvenile myelomonocytic leukaemia tumourigenicity

Recent progress of bacterial FtsZ inhibitors with a focus on peptides

Formation Mechanism for the TiN-MnS Complex Inclusions in Tire Cord Steel

Biallelic ERBB3 loss-of-function variants are associated with a novel multisystem syndrome without congenital contracture

Molecular and phenotypic spectrum of Noonan syndrome in Chinese patients

An optimized encoding algorithm for systematic polar codes

Biomineralization synthesis of HBc-CuS nanoparticles for near-infrared light-guided photothermal therapy

TRMA syndrome with a severe phenotype, cerebral infarction, and novel compound heterozygous SLC19A2 mutation: a case report

A recombinant fungal defensin-like peptide-P2 combats multidrug-resistant Staphylococcus aureus and biofilms

Prolonged high‐glucose exposure decreased SREBP‐1/FASN/ACC in Schwann cells of diabetic mice via blocking PI3K/Akt pathway

Clinical and mutation profile of pediatric patients with RASopathy-associated hypertrophic cardiomyopathy: results from a Chinese cohort

Optimized sleep strategy based on clustering in dense heterogeneous networks

Description of the molecular and phenotypic spectrum of Wiedemann-Steiner syndrome in Chinese patients

On the optimal flow allocation and information theoretically secure network coding design for multiple multicasts

A review of the design and modification of lactoferricins and their derivatives

Molecular dynamics simulations of aggregation behavior of sodium dodecyl sulfate on SiO₂ and CaCO₃ surfaces

Device-to-Device assisted wireless video delivery with network coding

Identification and analysis of the genetic causes in nine unrelated probands with syndromic craniosynostosis

Load Balanced Mobile User Recruitment for Mobile Crowdsensing Systems

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