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This paper presents the results in single cell intracellular penetration using the integrated dual nanoprobe-microfluidic system. Current technique for single cell penetration is using a manual controlled nanomanipulator which been attached with a nanoprobe. Due to this, successful single cell penetration depends on the operator skills. We proposed an integrated dual nanoprobe-microfluidic system...
We proposed a piezoelectric-actuated rigid nanoneedle for single cell wall cutting. A fabricated Tungsten (W) nanoneedle was assembled with a commercial piezoelectric actuator laterally and perpendicularly. The body of the nanoneedle is cylindrical while the shape of the tip is conical. Calibration of the assembled device was conducted using both experimental and numerical approaches. Experimentally,...
Electrical properties of a single cell can be used to infer about its physiological condition, e.g. cell viability. Conventional methods for electrical property measurement at single cell level are inaccurate, and have a slow throughput rate. Due to that, a dual nanoprobe-microfluidic system for electrical property measurement of single cells has been proposed. This paper is concerned about the mechanical...
Cell viability is important in biological studies. The detection of cell viability is simply checking whether the cell is alive or dead. This is important in experiments when cells are placed in a new foreign environment and when cells are being manipulated for testing either mechanically, chemically or electrically. Basically, there are two ways to determine the cell viability, one is through the...
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