Search results for: Yanshu Li

Items from 1 to 17 out of 17 results

article

Impact of fermentation through Wickerhamomyces anomalus and Saccharomyces cerevisiae on aroma and quality of mulberry wine

Yanshu Li, Yongkun Ma, Manqing Xu, Sanabil Yaqoob, more

International Journal of Food Science & Technology > 59 > 2 > 971 - 984

Wickerhamomyces anomalus D1‐4, a non‐Saccharomyces yeast known for its aroma production, offers a novel approach to improving the aroma and quality of mulberry wine. We employed various inoculation methods for fermenting mulberry wine and assessed its physicochemical, bioactive compounds, antioxidant activities, colour and aroma components. The results revealed that the addition of Wickerhamomyces anomalus...

article

Optimal contract arrangements for conservation on working forests

Changyou Sun, Bin Mei, Yanshu Li

Natural Resource Modeling > 35 > 4 > n/a - n/a

Forestland can be managed for timber and environmental goods simultaneously. A conservation contract allows a government agency to pay a landowner for the portion of property rights encumbered in the production of environmental goods. In this study, a theoretical model is developed to examine optimal contract provisions for carbon sequestration on working forests under a budget constraint for the...

article

A PAK5–DNPEP–USP4 axis dictates breast cancer growth and metastasis

Nanxi Geng, Yang Li, Wenyu Zhang, Fei Wang, more

International Journal of Cancer > 146 > 4 > 1139 - 1151

Although clinically associated with the progression of multiple cancers, the biological function of p21‐activated kinase 5 (PAK5) in breast cancer remains largely unknown. Here, we reveal that the PAK5–aspartyl aminopeptidase (DNPEP)–ubiquitin‐specific protease 4 (USP4) axis is involved in breast cancer progression. We show that PAK5 interacts with and phosphorylates DNPEP at serine 119. Functionally,...

article

Lead-induced iron overload and attenuated effects of ferroportin 1 overexpression in PC12 cells

Fankun Zhou, Ying Chen, Guangqin Fan, Chang Feng, more

Toxicology in Vitro > 2014 > 28 > 8 > 1339-1348

Lead (Pb) neurotoxicity has received renewed interest with the growing evidence that Pb contributes to Alzheimer’s disease (AD). However, the mechanism is not clear. In our previous study of long-term Pb exposure in vivo, a brain iron (Fe) overload induced by Pb was observedin elderly rats. It is well known that brain Fe overload is the mechanism of AD. Therefore, we have reason to believe that Pb...

article

miR-133 is a key negative regulator of CDC42–PAK pathway in gastric cancer

Zhenguo Cheng, Funan Liu, Guanqiao Wang, Yanshu Li, more

Cellular Signalling > 2014 > 26 > 12 > 2667-2673

Cell division cycle 42 (CDC42), an important member of the Ras homolog (Rho) family, plays a key role in regulating multiple cellular processes such as cell cycle progression, migration, cell cytoskeleton organization, cell fate determination and differentiation. Among the downstream effectors of CDC42, P21-activated kinases (PAKs) obtain the most attention. Although a large body of evidence indicates...

article

Age-dependent dopaminergic dysfunction following fetal exposure to atrazine in SD rats

Yanshu Li, Yan Sun, Junwei Yang, Yanping Wu, more

Environmental Toxicology and Pharmacology > 2014 > 37 > 3 > 1275-1282

The herbicide, atrazine (ATR), is used worldwide and its contamination in the environment has resulted in documented human exposure. It has also been shown that ATR results in dopaminergic neurotoxicity, however, few studies have investigated the long-term effects of ATR following in utero exposure. Therefore, we evaluated the effects of ATR exposure in Sprague Dawley rats during gestational on the...

article

Cetuximab inhibits oral squamous cell carcinoma invasion and metastasis via degradation of epidermal growth factor receptor

Wei Dai, Yanshu Li, Qing Zhou, Zhongfei Xu, more

Journal of Oral Pathology & Medicine > 43 > 4 > 250 - 257

Cetuximab (Erbitux, C225) is a chimeric monoclonal antibody that binds to the extracellular domain of epidermal growth factor receptor (EGFR), inhibiting tumor growth, invasion, angiogenesis and metastasis. However, the mechanisms underlying the effect of Cetuximab in human oral squamous cell carcinoma (OSCC) remain unclear. Here, we report that Cetuximab modulates EGFR protein stability through the...

article

The long-term effects of the herbicide atrazine on the dopaminergic system following exposure during pubertal development

Yanshu Li, Yan Sun, Junwei Yang, Yanping Wu, more

Mutation Research - Genetic Toxicology and Environmental Mutagenesis > 2014 > 763 > Complete > 23-29

Atrazine (2-chloro-4-ethylamino-6-isopropylamino-s-triazine) is used worldwide as a herbicide, and its presence in the environment has resulted in documented human exposure. Atrazine has been shown to cause dopaminergic neurotoxicity. The juvenile period is particularly vulnerable to environmental agents, but only few studies have investigated the long-term effects of atrazine following exposure during...

article

P21‐Activated Kinase 4 Regulates the Cyclin‐Dependent Kinase Inhibitor P57^Kip2 in Human Breast Cancer

Yanshu Li, Di Wang, Hongyan Zhang, Chunyu Wang, more

The Anatomical Record > 296 > 10 > 1561 - 1567

The p21‐activated kinases have been implicated in the control of cell cycle progression. However, the biological mechanism underlying the role of p21‐activated kinase 4 (PAK4) in cell cycle control remains unknown. Here, by using quantitative RT–PCR and immunoblot analyses, we discovered that over‐expression of PAK4 could suppress cyclin‐dependent kinase inhibitor 1C (p57^Kip2) expression in the MCF‐7...

article

Corrigendum to “The effect of lead exposure on brain iron homeostasis and the expression of DMT1/FP1 in the brain in developing and aged rats” [Toxicol. Lett. 216 (2013) 108–123]

Gaochun Zhu, Guangqin Fan, Chang Feng, Yanshu Li, more

Toxicology Letters > 2013 > 218 > 3 > 308

article

The effect of lead exposure on brain iron homeostasis and the expression of DMT1/FP1 in the brain in developing and aged rats

Gaochun Zhu, Guangqin Fan, Chang Feng, Yanshu Li, more

Toxicology Letters > 2013 > 216 > 2-3 > 108-123

The relation between lead (Pb) and iron (Fe) becomes increasingly concerned because they are both divalent metals that are absorbed by the same intestinal mechanism, and Pb exposure and Fe deficiency in the developmental brain, as well as Fe overload in the aged brain, can cause cognitive deficits. However, the interaction between Pb exposure and Fe status in the brain has not been established. Therefore,...

article

Lead-induced ER calcium release and inhibitory effects of methionine choline in cultured rat hippocampal neurons

Guangqin Fan, Fankun Zhou, Chang Feng, Fengyun Wu, more

Toxicology in Vitro > 2013 > 27 > 1 > 387-395

Lead, a ubiquitous neurotoxicant, can result in learning and memory dysfunction. Long term potentiation in the hippocampus, a potential neural substrate for learning and memory, is thought to be linked to calcium-triggered intracellular events. In this study, laser scanning confocal microscopy was used to examine the effects of Pb ²⁺ on intracellular and endoplasmic reticulum free calcium...

chapter

Bifurcation and stability study in coupling nonlinear rotating machinery's system under the influence of time-varying stiffness

Shuang Liu, Yanshu Li, Minjia He, Bohua Wang, more

Proceedings of the 10th World Congress on Intelligent Control and Automation > 1263 - 1268

2012 10th World Congress on Intelligent Control and Automation (WCICA 2012)

Considering unstable oscillation in the process of rotating machinery caused by changing in load lubrication and gear meshing stiffness in shaft system, the coupled nonlinear dynamic equation of rotating mechanical drive system is established with time-varying stiffness and nonlinear friction force based on Lagrange theory. The average equation of system is solved with the aid of method of multiple...

article

Nucleo-cytoplasmic shuttling of PAK4 modulates β-catenin intracellular translocation and signaling

Yan Li, Yangguang Shao, Yuxin Tong, Tao Shen, more

BBA - Molecular Cell Research > 2012 > 1823 > 2 > 465-475

The canonical Wnt/β-catenin signaling pathway plays a central role in development and cancer. The p21-activated kinase 4 (PAK4) involves in a wide range of cellular processes, including cytoskeletal reorganization, cell proliferation, gene transcription and oncogenic transformation. However, the cross talk between the Wnt and PAK4 signaling pathways is poorly understood. Here, we show that PAK4 is...

article

The effect of anti‐TfR mouse/human chimeric antibody on anti‐transplant rejection

Qing Ye, Zhihua Wang, Yanshu Li, Shuo Wang, more

Transplant International > 24 > 2 > 167 - 174

The expression of TfR/CD71 in T‐cell surface plays a pivotal role in T‐cell activation and proliferation. Anti‐human‐TfR monoclonal antibody could be used as an immunosuppressant in transplant therapy because of their potential to suppress T‐cell responses to alloantigens. We therefore examined the feasibility of an anti‐human‐TfR chimeric antibody (D2C) in suppression of T‐cell activation in vitro...

article

DGCR6L, a novel PAK4 interaction protein, regulates PAK4-mediated migration of human gastric cancer cell via LIMK1

Xiaodong Li, Qiang Ke, Yanshu Li, Funan Liu, more

International Journal of Biochemistry and Cell Biology > 2010 > 42 > 1 > 70-79

Overexpression, genetic amplification and mutations of p21-activated kinase 4 (PAK4) were found in a variety of human cancers. PAK4 regulated actin cytoskeleton reorganization by phosphorylating LIMK1 and promoted cancer cells migration. Using yeast two-hybrid screen, we identified a novel PAK4 binding protein, DGCR6L, which was associated with cancer cell metastasis. We confirmed PAK4 binding to...

article

Forest endowment, logging restrictions, and China's wood products trade

Daowei ZHANG, Yanshu LI

China Economic Review > 2009 > 20 > 1 > 46-53

This paper uses the gravity model to investigate determinants of China's wood products trade from 1995 to 2004. The results suggest that trade partners' forest resource endowment and China's own logging restrictions policy affect its wood products imports and exports. China's exported wood products are shown to be inferior goods while China's imported wood products are labor intensive for the exporting...

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