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The scavenger receptor cysteine‐rich (SRCR) domain is a key constituent in diverse proteins. N‐glycosylation is important in protein expression and function. In the SRCR domain of different proteins, N‐glycosylation sites and functionality vary substantially. In this study, we examined the importance of N‐glycosylation site positions in the SRCR domain of hepsin, a type II transmembrane serine protease...
Cell membrane‐bound serine proteases are important in the maintenance of physiological homeostasis. Hepsin is a type II transmembrane serine protease highly expressed in the liver. Recent studies indicate that hepsin activates prohepatocyte growth factor in the liver to enhance Met signaling, thereby regulating glucose, lipid, and protein metabolism. In addition, hepsin functions in nonhepatic tissues,...
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