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Collagen is believed to be one of the principal load bearing components of skin. This implies that deformation of collagen microfibrils play an important role in determining the extent of skin deformation under applied loads. We have developed a novel technique for generating internal strain maps of bundles of collagen microfibrils in the skin. The technique relies on digital image correlation (DIC)...
Skin impedance is an excellent surrogate marker of skin permeability. Physical and chemical modalities that serve to increase skin permeability have direct applications in transdermal drug delivery. We have shown that the electrical impedance of skin, and consequently its permeability, can be changed by up to 60% by uniaxial stretching. This is of significant because electrical impedance has been...
Collagen fibrils contribute to the structural integrity and crack resistance of bone, but their response to stress while in bundles of fibrils is not well known. Digital image correlation (DIC) is a powerful technique for measuring strain by comparing images of deformed samples to non-deformed samples, while second harmonic generation microscopy (SHGM) captures bright, high contrast images of bone...
Reprogramming of cells for delivery of proteins at specific sites holds great promise for future clinical applications. Chitosan delivery agents in form of nano-spheres presents a readily available biodegradable option for controlled release of mRNA in the cytosol of the cells. In this work we are using Enhanced Green Fluorescent protein as a proof of concept to show for transfection of osteoblast...
Second-order RC filters are synthesized using two voltage amplifiers with gains A1 and A2. As the natural frequency depends on A1 only, and the damping factor depends on A1 and A2, these factors can be chosen consecutively by varying the two gains. The passive components need not have variable or accurate values. This feature is particularly useful in the realization of filters operating below 1 Hz,...
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