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Oxygenated sterols (2–16) were synthesized by skeletal rearrangement of steroidal allylic alcohols. All the derivatives were screened for their anti-leishmanial activities. Compounds 3, 11 and 12 showed potent activities. Compound 12 was found least toxic and induced highest nitric oxide (NO) at 48h. Least toxicity of compound 12 on splenocytes validated its best anti-amastigote effect and induction...
A novel method for the partial synthesis of the rare triterpenoid, 3-epihydroxy lup-20(29)-en-19(28)-olide, and 1 from betulinic acid is reported. The binding efficiency, mode of binding for different compounds to the central catalytic domain of topoisomerase IIα, was calculated from a complete 3D molecular docking study on the crystal structure of the enzyme (1bgw, pdb). The compounds 1, 2b, and...
The field of Underwater Sensor Networks attempts to set up a Wireless Sensor Network (WSN) underwater for the purpose of exploration and monitoring by addressing challenges unique to the oceanic environment. In an UnderWater Sensor Network (UWSN), the knowledge of the location of a node can both improve the operation of the network (e.g. geographical routing) and add significance to the data that...
A number of green technologies such as Smart Power Grids, Smart Buildings, Smart Industrial Process and Smart Transportation rely on sensor technology. Sensor networks consist of a network of autonomous sensors that can reconfigure themselves so as to sense the environment in the most efficient manner. However, a significant challenge in the practical application of sensor networks is the need for...
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